白芍总苷联合较小剂量甲氨蝶呤治疗老年起病类风湿关节炎研究

Study of total glucosides of paeony combined with low dosage methotrexate on elderly onset rheumatoid arthritis

目的观察白芍总苷联合较小剂量甲氨蝶呤治疗老年起病类风湿关节炎(EORA)的疗效和安全性。方法将66例活动性EORA患者随机分成2组,治疗组34例,口服白芍总苷2片,每日3次,甲氨蝶呤7.5 mg,每周1次。对照组32例,口服甲氨蝶呤15 mg,每周1次。疗程为24周。结果治疗组在6周、12周、24周时有效率分别为29%,61%和79%。而对照组分别为34%,66%和78%,12周和24周疗效2组相近(P均>0.05),但治疗组在日常生活能力、关节肿胀指数、关节肿胀数、关节压痛数和双手平均握力等指标方面的改善优于对照组(P均<0.05),且不良反应发生率较对照组少(P<0.05)。结论白芍总苷联合较小剂量甲氨蝶呤治疗老年起病类风湿关节炎为有效、安全方案。

Objective It is to observe the curative effect and safety of total glucosides of paeony （TGP） combined with low dosage methotrexate on elderly onset rheumatoid arthritis （EORA）. Methods 66 cases of activity EORA were randomly divided into two groups. 34 cases in treatment group were treated with TGP two pieces three times a day and methotrexate 7. 5 mg once a week. 32 cases in control group were treated with methotrexate 15 mg once a week. The periods of treatment were both 24 weeks. Results The effective rates in experiment group at 6 weeks, 12 weeks and 24 weeks were respectively 29%, 61% and 79%, and that in control group were respectively 34%, 66% and 78% . The efficacy of two group was near at 12 weeks and 24 weeks （P 〉 0.05）. But treatment group were superior to control group at some index include ADL score, strength, index of joint tenderness and swelling （P〈 0.05）. The adverse effect rate in treatment group were fewer than that in control group （P〈 0.05）. Conclusion TGP combined with low dosage methotrexate is effective and safe scheme on elderly onset rheumatoid arthritis.