肽脱甲酰化酶抑制剂的合成及其抑菌活性

Synthesis of Peptide Deformylase Inhibitor and Their Bacteriostasis Activity

通过对肽脱甲酰化酶抑制剂构效关系的研究,以放线酰胺素为先导化合物,设计并合成了一系列异噁唑类化合物。其结构经1H NMR,IR,MS和元素分析表征。生物活性实验表明,该类化合物对标准肺炎克雷白球菌有显著的抑菌活性。

According to the structure-activity relationship of peptide deformylase inhibitors, a series of hydroxamic acid derivatives containing isoxazole were designed and synthesized based on the structure of actinonin. The structures of compounds were characterized by ^1H NMR, IR, MS and elemental analysis. The preliminary biological test showed that some compounds exhibited bacteriostasis activities.