胆酸甲酯(甲基)丙烯酰基衍生物的合成

Preparation of (Methyl)acryloyl Derivatives of Cholic Acid Methyl Ester

以（甲基）丙烯酰氯为酰化剂，三乙胺做缚酸剂合成了分子中含有1-3个（甲基）丙烯酰基的胆酸衍生物。结果显示，以酰氯作酰化试剂，胆酸甲酯分子中3个羟基的反应活性顺序是：C^3-OH〉C^12-OH〉C^7-OH。

（Methyl） acryloyl derivatives of cholic acid methyl ester with 1 - 3 （methyl） acryloyl groups have been synthesized by the use of （methyl）acryloyl chloride as a acylating reagent, triethylamide as a acid-binding reagent. Under the experiment conditions, the reactivity order of the three secondary hydroxyl groups of cholic acid methyl ester is C^3-OH〉C^12-OH〉C^7-OH.