杏丁注射液对阿霉素肾病大鼠肾小球损害的影响

Effects of Xingding injection on glomerulosclerosis in rats treated with adriblastine

目的探讨杏丁注射液对阿霉素肾病大鼠肾小球损害的保护作用。方法对3组SD系雌性大鼠分别给予生理盐水、阿霉素、阿霉素+杏丁注射液尾静脉注射处理,分时段检测3组大鼠的24 h尿蛋白量,对比测量血清总胆固醇、总蛋白、白蛋白以及肌酐,镜下观察实验大鼠肾脏组织,比较肾小球硬化率及系膜增生率。结果与对照组比较,实验组第8周时24 h尿蛋白及血清肌酐含量显著降低,血清白蛋白含量明显高,该三项指标差异有统计学意义(P<0.05),血清总胆固醇、总蛋白差异无统计学意义(P>0.05);镜检显示,对照组肾小球硬化率(36±7)%、肾小球系膜增生率(42±11)%,均高于实验组的(12±5)%和(17±8)%(P<0.05)。结论杏丁注射液能降低阿霉素肾病大鼠的24 h尿蛋白及血清肌酐含量,能抑制病变肾组织的肾小球硬化和肾小球系膜增生,对肾脏损害有明显的保护作用。

Objective To investigate the effectiveness of Xingding injection on glomeruloscerosis in rats treated with adriblastine. Methods Twenty-four rats were randomly divided into three groups. The rats in three groups were injected with normal saline （NS）, NS associated with adriblastine, adriblastine associated with Xingding injection respectively. The content of protein in urine of 24 hours and total cholesterol （Chol）, total protein （TP）, albumin （Alb）, creatinine （Cr） in serum were detected. Resets In Xingding group, the contents of protein in urine of 24 hours and Cr in serum were significantly lower, and that of serum Alb was significantly higher compared with those of the control group （ P 〈 0. 05 ）. By the observation of microscope, the rates of glomerulosclerosis and mesangial cell were （ 36 ± 7） % and （42 ± 11 ）% respectively in the control group, which were significantly higher than those of the Xingding group （ P 〈 0.05 ）. Conclusion Kidney damage of rats caused by adriblastine can be remarkably inhibited by the treatment of Xingding injection.