CD44v6和P16蛋白表达与胃癌浸润和转移的关系

The relationship between the expression of CD44v6,P16 protein and invasion and metastasis in gastric carcinoma

目的探讨CD44v6和P16蛋白表达与胃癌浸润、转移的相关性。方法应用免疫组化CSA法检测110例胃癌组织中CD44v6和P16蛋白表达。结果110例胃癌中CD44v6和P16蛋白阳性表达分别为72.7%(80/110)和47.3%(52/110)。CD44v6蛋白高表达及P16蛋白低表达与胃癌TNM分期、浆膜浸润、淋巴结转移和肝脏转移均呈正相关关系(P<0.05)。胃癌中CD44v6表达与P16表达呈负相关(r=-0.589,P<0.05)。结论CD44v6和P16蛋白表达与胃癌浸润、转移密切相关。检测二者基因表达产物均可作为预测胃癌浸润、转移的客观指标。

Objective To explore the relationship between the expression of CD44v6, P16 protein and the invasion and metastasis in gastric carcinoma and to investigate the correlation between the expression of CD44v6 and P16 protein. Methods methods were used to detect the expression of CD44v6 and P16 protein in 110 cases of gastric carcinoma. Results In 110 cases of gastric carcinoma, the expression of CD44v6 and P16 protein were 72. 7% （80/110）and 47. 3% （52/110）respectively. The high level expression of CD44v6 protein and low level expression of P16 protein were positively correlated with the TNM staging, serosa infiltration, lympho node and liver metastasis of gastric carcinoma （ P 〈 0. 05 ）. The expression of CD44v6 protein was negatively correlated with the expression of P16 （ r = -0. 589, P 〈 0. 05）. Conclusion The expressions of CD44v6 and P16 protein are closely correlated with the invasion and metastasis in gastric carcinoma. The levels of CD44v6 and P16 protein may be used as objective indexes for the prognosis of invasion and metastasis in gastric carcinoma.