儿童恶性癫痫性脑病非药物治疗新进展

Advance in Nonpharmacologic Therapy for Child Catastrophic Epileptic Encephalopathy

恶性癫痫综合征患儿具有显著的神经认知倒退、精神发育迟滞和难以控制的发作。对于这种孩子,非药物治疗是一种非常重要的治疗方法。现讨论手术治疗、迷走神经刺激法和生酮的膳食疗法等在婴儿痉挛症、Lennox-Gastaur综合征和进行性肌阵挛癫痫中的作用。同时根据恶性癫痫综合征的类型、治疗特点选择非药物治疗对减少发作、促进发育及行为改善的依据。

There are remarkable noetic retropulsion ,mental retardation and difficultly controlled seizure in children with catastrophic epilepsy syndromes. For these children, nonpharmacologic interventions are important aspects of a comprehensive treatment plan. The effects of epilepsy surgery, vagus nerve stimulation, and the ketogenic diet on infantile spasms, Lennox-Gastaut syndrome, and progressive myoclonic epilepsy are discussed,including the basis of nonpharmacologic treatment which is selected according to the types of catastrophic epilepsy and therapeutic characteristics on reduction of seizure frequency, progress in development or improvement of behavior.