单纯性肥胖患者血清胰淀素水平与体成分的相关性研究

Association study of serum amylin level and body composition in simple obese patients

目的:利用生物电阻抗仪和多层螺旋CT研究单纯性肥胖患者血清胰淀素水平与体脂及腹部内脏脂肪和皮下脂肪的相关性。方法:检测36例单纯性肥胖患者腰围、血压、血糖、血脂、胰岛素和胰淀素,生物电阻抗仪测体成分,螺旋CT测腹部脂肪,与35例正常对照者比较,并做胰淀素与各指标间的相关性分析。结果:单纯性肥胖患者的空腹血清胰淀素较正常人显著增高(P<0.05),并与腹部皮下脂肪体积呈负相关(r=-0.786,P<0.05),与体脂含量无相关性,与血清总胆固醇呈负相关(r=-0.475,P<0.05)。结论:单纯性肥胖患者存在高胰淀素血症和胰淀素抵抗,胰淀素在人体内是否是反映体内脂肪储存的信号有待于进一步研究。

Objective： To study the relation of serum amylin level to body fat mass by bioelectrical impedance analysis, abdominal visceral fat volume and subcutaneous fat volume by multi-slice spiral CT in simple obese patients. Methods： Waist circumference, blood pressure, blood glucose, serum lipids, insulin, amylin were measured, and body composition and abdominal fat volume were respectively detected by bioelectrical impedance analysis and spiral CT in 36 obese patients and compared with the results from 35 controls. Correlation was analyzed between anlylin and other indexes. Results： Serum amylin of simple obese patients was much higher than that of controls（ P 〈 0.05）. In simple obese patients, serum amylin was negatively associated with plasma total cholesterol（ r = -0.475, P 〈 0.05） and with abdominal subcutaneous fat volume （ r = - 0.786, P 〈 0.05）, but not with body fat mass.Conclusion： Obese subjects exhibit hyperamylinemia and amylin resistance, whether amylin is one of adiposity signals or not is worthy of being further explored.