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120甘草酸及甘草次酸的药理学研究进展 被引量：35

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摘要 甘草的主要成分甘草酸及其代谢产物甘草次酸具有诸多药理活性,包括传统的抗炎、免疫调节、抗肝损伤,及现今的研究热点抗病毒及抗肿瘤作用。笔者就10年来对甘草酸以及甘草次酸国外药理学进展、及其作用机制研究做一综述。
作者 刘彬 齐云
机构地区 中国医学科学院中国协和医科大学药用植物研究所
出处 《国外医药（植物药分册）》 2006年第3期100-104,共5页
关键词 甘草酸 甘草次酸 甘草甜素 免疫调节 抗肿瘤 抗病毒 保肝 药理学
分类号 R285.6 [医药卫生—中药学] R285.5 [医药卫生—中药学]
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参考文献47

  • 1Ohtsuki K, Abe Y, Shimoyama Y, et al. Separation of phospholipase A2 in Habu snake venom by glycyrrhizin (GL)-affinity column chromatography and identification of a GL-sensitive enzyme. BiolPharmBull, 1998, 21(6): 574-578
  • 2Matsui S, Matsumoto H, Sonoda Y, et al. Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line. Int Immunopharmacol, 2004, 4(13):1633-1644
  • 3Sakamoto R, Okano M, Takena H, et al. Inhibitory effect of glycyrrhizin on the phosphorylation and DNA-binding abilities of high mobility group proteins 1 and 2 in vitro. Biol Pharm Bull, 2001, 24(8): 906-911
  • 4Yoshikama M, Matsui Y, Kawamoto H, et al. Effects of glycyrrhizin on immune-mediated cytotoxicity. J Gastroenterol Hepatol, 1997, 12(3): 243-248
  • 5Oh C, Kim Y, Eun J, et al. Induction of T lymphocyte apoptosis by treatment with glycyrrhizin. Am J Chin Med, 1999, 27(2): 217-226
  • 6Zhang Y H, Kato M, Isobe K, et al. Dissociated control by glycyrrhizin of proliferation and IL-2 production of murine thymocytes. Cell Immunol, 1995, 162(1): 97-104
  • 7Nakajima N, Utsanomiya T, Kobayashi M, et al. In vitro induction of anti-type 2 T cells by glycyrrhizin. Burns, 1996, 22(8) : 612-617
  • 8Dai J H, Iwatani Y, Ishida T, et al. Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages. Immunology, 2001, 103(2): 235-243
  • 9Raphael T J, Kuttan G. Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system. Phytomedicine, 2003, 10 (6/7): 483-489
  • 10Van Rossum T G, Vulto A G, De Man R A, et al. Review article: glyeyrrhizin as a potential treatment for chronic hepatitis C. Aliment Pharmaeol Ther, 1998, 12(2): 199-205

二级参考文献23

  • 1李铁民,梁再赋.甘草甜素免疫调节作用研究进展[J].中草药,1993,24(10):553-556. 被引量：23
  • 2李诚秀,黄能慧,李玲,罗俊.甘草甜素对抗癌药活性及毒性的影响[J].贵阳医学院学报,1996,21(3):183-185. 被引量：13
  • 3Morrissery J Klahr S.Transcription factor NF-κ B regulation of renal fibrosis during ureteral obstruction[J].Seminars in Nephrology,1998,18:603-611.
  • 4Hong Y, Nakashima I, Isobe K. Enhancement of nitric cxide preduction from activated macrophages by glycyrrhizin[J]. Am J Chin Med,1996,24(3-4) :271-278.
  • 5Liew FY, Cox FE. Nonspecific defence mechanism: the mole of nitric oxide[J]. Immunoparasitology Today, 1991,12(3): A17-A21.
  • 6Hibbs JB Jr, Taintor RR, Vavrin Z. Macrophage cytotoxicity: role for L-argininedeiminase and imino nitrogen oxidation to nitrite[J]. Science, 1987,235(4787) :473-476.
  • 7Stuehr DJ, Nathan CF. Nitric Oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells[J]. JExp Med, 1989,169(5): 1543-1555.
  • 8渡伸三.甘草甜素对致癌物致肝癌的保护作用[J].国外医学：中医中药分册,1981,3(5):35-37.
  • 9Nishino H, Yoshika K, lwashima A, et al. Glycyrthetic acid inhibits tumor-promotingactivity of teleocidin and 12-o-tetradecanoylphorbol-13-acetate in two stage mouse skin carcinogenesis[J]. Jpn J Cancer Res Gann, 1986,77(1) :33-36.
  • 10Agarwal R, Wang ZY, Mukhtar H. Inhibition of mouse skin tumorinitiating activity of dmba by chronic oral feeding of glycyrrhizin in drinking water[J]. Nutr Cancer, 1991,15(3-4): 187-193.

共引文献32

同被引文献477

引证文献35

二级引证文献343

国外医药（植物药分册）
2006年 第3期

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