0.75%左旋布比卡因硬膜外阻滞用于剖宫产术的临床研究

Clinical study on 0.75% Levebupivacaine in epidural anesthesia for caesarean section

目的:对比观察0.75%左旋布比卡因与0.5%布比卡因用于剖宫产手术硬膜外麻醉时临床麻醉效果和对新生儿的影响。方法:选择剖宫产术病人40例,随机分为两组,硬膜外麻醉用药分别采用0.75%左旋布比卡因(A组)或0.5%布比卡因(B组)。观察两组感觉及运动阻滞效果,低血压、恶心、呕吐等副作用发生情况,以及新生儿一般状况。结果:A组感觉阻滞起效较快,持续时间较长,两组运动阻滞效果无明显差别,两组低血压、恶心、呕吐发生率无显著差异。结论:0.75%左旋布比卡因与0.5%布比卡因相比,感觉阻滞起效较快,持续时间较长,运动阻滞效果相似。

Objective： To compare the clinical efficacy, side effects and neonatal state of 0. 75 % Levebupivacaine and 0. 5% Bupivacaine in epidural anesthesia for cesarean section. Methods： 40 patients undergoing cesarean section were randomly divided into two groups. The patients were given 0. 75% Levebupivacaine （group A） and 0. 5 % Bupivacaine （ B group） for epidural anesthesia respectively. Observing the efficacy of sensory and motor block. Checking and recording the possible adverse effects such as hypotension, nausea, vomiting and neonatal state. Results： The onset time of sensory block of group A was significantly faster and continuing longer than that of group B. There were no significant differences between two groups in motor block. They also had a little more hypotension, nausea, vomiting but the difference were not significant. Conclusion： Compared with 0. 5% Bupivacaine, 0. 75% Levebupivacaine provides more satisfactory sensory block and similar motor block, and have no significant effect on neonates.