男性不育患者266例细胞遗传学分析

Cytogenetic analysis of 266 patients with male infertility

目的:探讨男性不育患者的细胞遗传学基础。方法:对266例男性不育患者进行细胞遗传学分析。结果:266例中异常核型66例,占全部被检者的24.81%。异常核型中,52例(78.79%)为克氏综合征;6例(9.09%)为大Y染色体;6例(9.09%)为常染色体结构异常;1例(1.52%)为46,XY,del(y),(q11);1例(1.52%)为46,XX男性综合征。结论:染色体异常是男性不育的主要原因之一。男性不育患者中,克氏综合征是最主要的染色体异常的类型,与其他类型相比,该综合征有其典型的临床表现。

Objective ：To probe the cytogenetic base on male infertility patients. Methods：The chromosome karyotypcs of 266 male infertility patients were analyzed by cytogenetic method. Results： Among 266 cases, 66 cases （24.81% of total patients） showed abnormal karyotypcs,including 52 cases （78.79% of totality） of Klinefelter syndrome, 6 cases of Yqh ＋ , 6 cases of chromosome structure abnormality,one case of 46, XY, del （y）, （qll） and one case of 46, XX male syndrome. Conclusions： Chromosome abnormality is an important cause in male infertility, which has serious effect on the growth of male. Klinefeher syndrome is the main type of chromosome abnormality in male infertility. Comparing with others, its symptom is very typical.