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左房室瓣置换术中应用氨溴索患者血栓素及前列腺环素变化的研究 被引量:1

The changes of TXB_2 and 6-keto-PGF_1a with using ambroxol in replacement of mitral valve in beating heart
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摘要 目的探讨心脏不停跳左房室瓣置换术中应用氨溴索(沐舒坦)肺保护的效果。方法风湿性心脏病患者36例随机分为实验组(应用沐舒坦)与对照组(不用沐舒坦)。体外循环(CPB)90min。于6个时点采静脉血,分别检测检测血浆血栓素(TXB2)和前列腺环素(6-keto-PGF1a)。结果两组CPB期间TXB2与CPB前比较均有不同程度升高,实验组与对照组TXB2和6-keto-PGF1a在CPB中各时点差异均有统计学意义(P<0.05)。结论TXB2可作为CPB过程中检测肺保护效果的敏感指标;心脏不停跳左房室瓣置换术中应用氨溴索(沐舒坦)可以减少TXB2的释放,具有较佳的肺保护效果。 Objective To study the predictive effect of ambroxol in replacement of mitral valve in beating heart. Methods Thirty-six patients underwent mitral valve replacement were randomly divided into experimentel group( use ambroxol in beating heart, n = 18) and control group(use accrue-brinein beatingheart, n = 18 ). Cardiopulmonary bypass(CPB) was performed for 90 minutes. Plasma thromboxane B2 (TXB2) and epoprostenol (6-keto- PGF1a) of tow groups were respeptively measured and contrasted at six different time intervals. Results TXB2 in control group increased more quickly,6-keto-PGF1a in experimental group increased more quickly. Conclusion Plasma TXB2 may be a sensitive detective guideline in lung protective effects. Beating heart is propitious to reduce the release of TXB2 ,and to increase the release of 6-keto-PGF1a.
出处 《中国基层医药》 CAS 2006年第4期537-538,共2页 Chinese Journal of Primary Medicine and Pharmacy
基金 广西自治区教育厅课题资助(2004129)
关键词 风湿性心脏病 心脏瓣膜 人工 心肺转流术 氨溴索 花生四烯酸类 依前列醇 Rheumatic heart disease Heart valve prosthesis Cardiopulmonary bypass Mecysteine Arachildonic acids Epoprostenol
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  • 1Piotrowski WJ,Pietras T,Kurmanowska Z,et al.Effect ofparaquat intoxication and ambroxol treatment on hydrogen per-oxide production and lipid peroxidation in selected organs of rat.J Appl T Oxicol,1996,16(6):501-507.
  • 2王晓秋.沐舒坦雾化吸入治疗老年呼吸道感染疗效观察[J].福建医药杂志,2003,25(1):85-85. 被引量:63
  • 3Joues G,Flurley JV.The effect of prostacyclin on the adhesion of leucocytes to injured vascular endothelium.J Pathol,1984,142:51-59.
  • 4Jahr J,Ekelund U,Grande PO.In vivo effects of prostacyclin onsegmental vascular resistances,on myogenic reactivity,and oncapillary fluid exchange in cat skeletal muscle.Crit Care Med,1995,23:523-531.
  • 5Huang JZ,Yang ZH,Wang ZG,et al.Study on charac-teristics of blast-fragment combined injury in dogs.J Trauma,1996,40:63-67.
  • 6何巍,林辉,郑宝石,曾建业,可金星,肖桃元.浅低温体外循环心脏跳动中施术对心肌保护的实验研究[J].中华胸心血管外科杂志,2001,17(2):96-98. 被引量:110

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