原发性痛风的危险因素分析

The analysis of the risk factors of primary gout

目的探讨原发性痛风的危险因素。方法对420例原发性痛风患者进行回顾性分析。结果420例中,男女比例21∶1,男性明显多于女性;女性平均发病年龄显著高于男性,而平均病程则短于男性。28%患者年龄<40岁。有家族史者平均发病年龄也显著小于无家族史者。38%患者有长期嗜酒史,54%有嗜肉、海鲜等高嘌呤饮食史。平均体重(74.7±9.9)kg,体块指数(27.3±2.6)。诱发痛风急性发作的诱因包括暴饮暴食、劳累、感染、手术、外伤等。结论年龄、性别、遗传素质、饮食习惯、肥胖、高脂血症、肾功能不全等是痛风的危险因素。而暴饮暴食、劳累、感染、手术、外伤、使用利尿剂以及受寒等因素可诱发痛风的急性发作。本病发病年龄有年轻化倾向,值得重视。

Objective To investigate the risk factors of primary gout. Methods 420 patients with primary gout were analyzed. Results Among the 420 patients, male to female ratio was 21 ： 1. Average onset age of female was significantly higher than that of the male, whereas, the mean disease duration was significantly shorter in female than that in male. The mean disease duration of patient with positive familial history was significantly shorter than that with negative ones. 38 % patients had an alcohol abuse history, and 54 percent patients had had high purin food intake. Mean weight of body was （74.7± 9.9）kg,and average body mass index（BMI） was （27.3± 2.6）. Events of inducing acute attack included engorgement,tire,infection,operation and trauma, Conclusion Risk factors of primary gout include age,sex, inherity, food habit, hyperlipemia, renal function failure. Engorgement, tire, infection, operation,trauma and use of diuretics could induce gout acute attack. It should be taken importance to that the onset age shows a young tendency.