华蟾素联合肝动脉化学药物栓塞治疗原发性肝癌疗效观察

Effects of huachan-shu injection combind with transcatheter arterial chemoembolization on patients with advanced unresectable hepatocelluler carcinoma

目的探讨华蟾素注射液联合肝动脉化学药物栓塞(TACE)治疗原发性肝癌(肝癌)近期疗效。方法将43例肝癌患者随机分为两组,治疗组(华蟾素注射液加TACE)21例,对照组(单纯TACE)22例。观察患者治疗前后临床主要症状的变化。结果治疗组和对照组的显效、无效,分别6、9、3例和3、5、11例,治疗组总有效率(77%)显著优于对照组(51.37%)(P<0.05),两组治疗后AFP比治疗前均有下降,但治疗组优于对照组(P<0.01),且生活质量评分明显改善。结论华蟾素联合肝动脉栓塞化疗可以有效延长患者的生命,改善生活质量,对失去手术机会的肝癌患者是有效方法之一。

Objective To evaluate the short term clinical effect in treating hepatocelluler carcinoma combined transcatheter arterial chemoembolization（TACE） with huachan-shu injection. Methods Forty-three patients suffered with hepatoeelluler carcinoma（HCC） were randomly divided into two groups. In the treatment groups,21 patients received Huaichan-shu injection after TACE, and 22 patients in the control group were treated with TACE simply,the serum a-fetal protein（AFP） was detected by raido-immunologieal technology. At the sam time, the observed indexes including the changes of symptoms and signs, side effects, ultra -sound, CT and liver or kidney fuctions were considered. Results In the treatment group. Six cases were evaluated as CR,9 PR and 3 NC. Compard with the control group CR,PR and NC were 3,3 and 11 cases respectively. The effective rate was 77 % in the treatment group, which was superion to the control group （51.37 % , P 〈 0.03）. AFP in the treatment group decreased more siginifieantly than that in the control group（ P 〈 0. 01 ）. conclusions The treatment for HCC combined huaichanshu injection with TACE can not holy inactivate the tumor cells effectively, but also improve the immune system function of the patients, it is an effective method for HCC patients who have lost the surgical chance.