血清游离态前列腺特异抗原检测在前列腺疾病诊断中的应用

Research on the clinical utilization of serum free PSA level in the diagnosis of prostate disease

目的 探讨血清游离态前列腺特异抗原（F-PSA）和总前列腺特异抗原（T-PSA）及F-PSA与T-PSA比值（F／T）在前列腺疾病诊断中的应用价值。方法采用ELISA方法测定28例良性前列腺增生（BPH）、21例前列腺癌（PCa）患者的血清F-PSA、T-PSA水平，并计算出相应的F／T值。结果两组患者T-PSA、F-PSA值差异有统计学意义（P〈0．05），其F／T比值差异有统计学意义（P〈0．01），在PSA的诊断灰区（T-PSA值4．0～10tμg／L），两组患者的T-PSA差异无统计学意义（P〉0．05），但F-PSA、F／T比值差异有统计学意义（P〈0．05）。结论F-PSA及F／T比值的测定，可提高PSA对BPH及PCa（尤其在PSA诊断灰区）鉴别诊断的特异性。

Objective To research the clinical value of serum-free PSA（F-PSA）,total PSA（T-PSA） and F-PSA versus T-PSA（F/T） in differential diagnosis of BPH and PCa. Methods The level of serum-free prostate specific antigen and total prostate specific antigen were detected by ELISA in 28 cases of benign prostate hyperplasia （BPH） and in 21 cases of prostate caneer（PCa）. And F-PSA/T-PSA ratio was calculated. Results The levels of serum T-PSA, F-PSA were significantly different in two groups（ P 〈 0.05）, and the ratio（F/T） had significant difference（P〈0.01） ,in the diagnostic gray zone of PSA（the T-PSA value between 4.0- 10.0μg/L）,there was no significant difference of T-PSA among two groups（P 〉 0.05）, but F-PSA and the ratio（F/T） was significantly dif： ferent（P 〈 0.05）. Conclusion ＇With the detected F-PSA and F/T ratio,it can improve the diagnosis specificity of PSA among BPH and PCa（especially within the PSA diagnostic gray zone）.