超氧化物歧化酶对大鼠脑组织中过氧化脂质水平的影响

Effect of the Orally Administered Superoxidase Dismutase on the Lipoperoxide Levels of Rat Brain Tissues

观察大鼠服用超氧化物歧化酶（ＳＯＤ）后脑组织中过氧化脂质（ＬＰＯ）和ＳＯＤ水平变化。结果表明，ＬＰＯ含量高剂量组和低剂量组分别与对照组比较，有极显著意义（Ｐ＜０．０１）。ＳＯＤ高剂量组与对照组比较有极显著意义（Ｐ＜０．０１）；低剂量组与对照组比较有显著意义（Ｐ＜０．０５）。这表明，大鼠服用ＳＯＤ制剂可降低脑组织中的ＬＰＯ水平，同时提高ＳＯＤ水平，为ＳＯＤ的口服临床应用提供了依据。

The levels of LPO and SOD in 24 rat brain tissues were determined after SOD was administered orally for 45 days. The rats were divided into 2 groups at random. The first group and the second group were orally given SOD in the dosage of 1250 U/kg and 500 U/kg per day respectively.The third group of 12 rats was normal control.The results showed that the levels of LPO and SOD in the first group were 0.86±0.058nmol/mg·pr and 20.10±1.29U/mg·pr respectively,that the levels of LPO and SOD in second group were 1.203±0.045nmol/mg·pr and 19.50±1.95U/mg·pr respectively,that the levels of LOP and SOD in control group were 1.463±0.097nmol/mg·pr and 18.00±2.00U/mg·pr respectively. The statistical results showed that LPO levels of the first and the second group had very significant difference(P<0.01),the SOD level of first group had very significant difference(P <0.01),the SOD level of second group had significant difference( P<0. 05) compared with those of control group.The results proved that orally administered SOD could decrease the levels of LPO and increase the levels of SOD in brain tissues,which provided experimental evidence for the oral administration of SOD for application of anti-aging and anti-radiation etc.