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干细胞移植与转基因治疗建立生物起搏器的实验研究进展 被引量：1

The progress in restoring cardiac biological pacemaker by stem cells transplantation and gene therapy
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作者 任晓庆 浦介麟 王方正
机构地区 中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院心律失常诊治中心
出处 《中华心律失常学杂志》 2006年第2期150-152,共3页 Chinese Journal of Cardiac Arrhythmias
基金 国家自然科学基金资助项目(30370567)
关键词 转基因治疗 干细胞移植 实验研究进展 起搏器 生物 缓慢心律失常 心脏疾患 移植修复 治疗技术
分类号 R541.7 [医药卫生—心血管疾病]
  • 相关文献

参考文献15

  • 1Rosen MR,Brink PR,Conen IS,et al.Genes,stem cells and biological pacemakers.Cardiovase Res,2004,64:12-23.
  • 2Potapova I,Plotnikov A,Lu Z,et al.Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers.Circ Res,2004,94:952-959.
  • 3Miake J,Marban E,Nuss HB.Gene therapy:biological pacemaker created by gene transfer.Nature,2002,419:132-133.
  • 4Huebach JF,Graf EM,Leutheuser J,et al.Electrophysiological properties of human mesenchymal stem cells.J Physiol,2003,554:659 -672.
  • 5Strauer BE,Kornowski R.Stem cells therapy in perspective.Circulation,2003,107:929-934.
  • 6Valiunas V,Doronin S,Valiuniene L,et al.Human mesenchymal stem cells make cardiac connexins and form functional gap junctions.J Physiol,2004,555:617 -626.
  • 7任晓庆,浦介麟,张澍,贾玉和,赵欣然,孟亮,王方正.自体骨髓间叶干细胞诱导分化移植重建窦房结起搏功能的实验研究[J].中国循环杂志,2004,19(6):462-465. 被引量：15
  • 8Gepstein L.Derivation potential application of human embryonic stem cells.Circ Res,2002,91:866-876.
  • 9Plotnikov AN,Sosunov EA,Qu J,et al.A biological pacemaker implanted in the canine left bundle branch provides ventricular escape rhythms having physiologically acceptable rates.Circulation,2004,109:506-512.
  • 10Ederberg JM,Huang DT,Josephson ME,et al.Molecular enhancement of porcine cardiac chronotropy.Heart,2001,86:559-562.

二级参考文献18

  • 1王方正,张奎俊,方丕华,马坚,楚建民,华伟,田瑞国,陈柯萍,鲁志民,朱克平,孙瑞龙,陈新.射频消融治疗不适当的窦性心动过速一例[J].中华心律失常学杂志,1997,1(2):117-121. 被引量：9
  • 2Anversa P, Nadal-Ginard B. Myocyte renewal and ventricular remodelling. Nature, 2002, 415: 240-243.
  • 3Orlic D. Adult bone marrow stem cells regenerate myocardium in ischemia heart disease. AN YAS, 2003, 996: 152-157.
  • 4Chiu RC. Bone-marrow stem cells as a source for cell therapy. Heart Fail Rev, 2003, 8: 247-251.
  • 5Kadiyala S, Young RG, Thiede MA, et al. Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in vivo and in vitro. Cell Transplantation, 1997, 6: 125-134.
  • 6Tomita S, Mickle DA, Weisel RD, et al. Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J Thorac Cardiovasc Surg, 2002, 123: 1132-1140.
  • 7Makino S, Fukuda K, Miyoshi S, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest, 1999, 103: 697-705.
  • 8Fukuda K. Development of regenerative cardiomyocytes from mesenchymal stem cells for cardiovascular tissue engineering. Artif Organs, 2001, 25: 187-193.
  • 9Tomita S, Li RK, Weisel RD, et al. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation, 1999, 100(Suppl Ⅱ): Ⅱ247-256.
  • 10Kudo M, Wang Y, Wani MA, et al. Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart. J Mol Cell Cardiol, 2003, 35: 1113-1119.

共引文献14

同被引文献25

  • 1刘凡,刘坤申.生物起搏器与基因疗法[J].心血管病学进展,2004,25(B12):97-99. 被引量：3
  • 2Kerr CR, Connolly SJ, Abdollah H, et al. Canadian Trial of Physiological Pacing Effects of physiological pacing during long-term follow-up [ J]. Circulation, 2004,109(3) :357-362.
  • 3Lamas GA, Lee KL, Sweeney MO, et al. Mode Selection Trial in Sinus-Node Dysfunction. Ventricular pacing or dual-chamber pacing for. sinus-node dysfunction [J]. N Engl J Med, 2002,347(23) :1891-1892.
  • 4Andersen HR, Nielsen JC, Thomsen PE, et al. Long-term follow-up of patients from a randomised trial of atrial versus ventricular pacing for sick-sinus syndrome [J]. lancet, 1997,350(9086) :1210-1216.
  • 5Toff WD, Skehan JD, de Bono DP, et al. The United Kingdom pacing and cardiovascular events (UKPACE) trial. United Kingdom Pacing and Cardiovascu- lar Events [J]. Heart, 1997,78(3) :221-223.
  • 6Sweeney MO, Bank A J, Nsah E, et al. Search AV Extension and Managed Ventricular Pacing for Promoting Atrioventricular Conduction (SAVE PACe ) Trial. Minimizing ventricular pacing to reduce atrial 6brillation in sinus-node disease [J]. N Engl J Med, 2007,357(10) :1000-1008.
  • 7de Cock CC, Meyer A, Kamp 0, et aL Hemodynamic benefits of right ventricular outflow tract pacing: comparison with right ventricle apex pacing [ J ]. PACE, 1998,21 (3) :536-544.
  • 8Flevarl P, Lefiheriotis D, Fountoulaki K, et al. Long-term non-outflow septal versus apical right ventricular pacing: relation to left ventricular dyssynchrony [ J ]. Pacing Clin Electrophysiol, 2009,32 (3) :354-362.
  • 9Victor F, Mabo P, Mansour H, et al. A randomized comparison of permanent septal versus apical right ventricular pacing: short-term results [ J]. J Cardiovasc Electrophysiol, 2006,17 ( 3 ) :238-242.
  • 10Pachon MJC, Albornoz RN, Pachon MEI, et al. Right ventricular bifocal stimu- lation in the treatment of dilated cardiomyopathy with heart failure [ J ]. Arq Bras Cardiol, 1999,73 ( 6 ) :485-498.

引证文献1

二级引证文献3

中华心律失常学杂志
2006年 第2期

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