盐酸托烷司琼氯化钠注射液治疗化疗所致恶心、呕吐疗效和安全性的观察

Observation of the effect and security of tropisetron hydrochloride and sodium chloride injection on nausea and vomiting induced by chemotherapy

目的评价盐酸托烷司琼氯化钠注射液治疗含顺铂或阿霉素方案化疗所致恶心和呕吐的疗效和安全性。方法对入选的108例患者进行随机交叉对照设计,分AB、BA两组。AB组第一周期用盐酸托烷司琼氯化钠注射液,第二周期启用欧必停;BA组相反。化疗方案中顺铂(≥80mg/m2)分3d用,阿霉素(≥50mg/m2)在1d内给予,每21￣28d重复。结果AB和BA两组患者呕吐次数、恶心程度、两组第一二周期间差异无统计学意义(P>0.05)。盐酸托烷司琼和欧必停对生命体征无影响,按前者为8.3%、后者为11.1%,不良事件发生率两药间的差异无统计学意义(P>0.05)。结论盐酸托烷司琼氯化钠注射液治疗化疗药物所致恶心、呕吐安全有效。

Objective To evaluate the curative effect and security of tropisetron hydrochloride and sodium chloride injection.on the nausea and vomiting induced by cisplatin and adriamycin Methods One hundred and eight patients were divided into AB and BA groups by a randomized, cross-over design. Tropisetron hydrochloride and sodium chloride injection was taken in the first cycle and Onbiting was taken in the second cycle in AB group, while the administration was reversed in the BA group. The chemotherapy plan was as follows： cisplatin （≥ 80mg/m^2） given in three days and adriamycin（ ≥ 50mg/m^2） given in one day which was repeated every 21-28 days. Results There were not significant difference in vomiting times and degree of nausea in two groups and in two cycles（P〉 0.05）. Both tropisetron hydrochloride and sodium chloride injection and Onbiting had no influence on the vital signs, according that the former was 8.3% and the latter was 11.1%. There wasn＇ t significant difference in the adverse reaction rate of two groups. Conclusion Tropisetron hydrochloride and sodium chloride injection is safe and effective on nausea and vomiting induced by chemotherapy.