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聚类算法在基因表达数据分析中的应用研究

Research on Clustering Algorithms in Gene Expression Data Analyzing
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摘要 针对传统聚类算法在基因表达数据处理中的不足之处,讨论了与计算智能技术相关的两种算法:模糊C均值算法(FCM)和遗传K均值算法(GKA),对FCM算法中类别数c和模糊指数m的选取进行了比较深入的研究,最后用实验数据对各算法性能进行了分析和比较。 Aiming at the deficiencies of the traditional clustering algorithms in analyzing and handling gene expression data,two algorithms that associate with the computational intelligence FCM and GKA are discussed.Then the methods for selecting parameters are studied in detail.Lastly,the algorithms' performances are compared using experiment data.
作者 朱婵 许龙飞
出处 《计算机工程与应用》 CSCD 北大核心 2006年第15期171-175,178,共6页 Computer Engineering and Applications
基金 国家自然科学基金资助项目(编号:60374070) 广东省自然科学基金资助项目(编号:031903)
关键词 聚类分析 微阵列 基因表达数据 计算智能 clustering analysis,microarrays,gene expression data,computational intelligence
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参考文献15

  • 1Jia wei Han.Micheline Kamber.范明,孟小峰译..数据挖掘:概念与技术[M]..北京:机械工业出版社,,2002..223~257..
  • 2王富刚,陈先农.基因芯片数据的聚类分析[J].国外医学(生物医学工程分册),2004,27(2):98-101. 被引量:8
  • 3Annaka Kalton,Kiri Wagstaff,Jungsoon Yoo.Generalized Clustering, Supervised Learning,and Data Assignment[J].KDD ,2001;(1):299-304
  • 4J C Bezdek.Pattem Recognition with Fuzzy Objective Function Algorithms[M].New York:Plenum Press,1987
  • 5Yager R R,Filev D P.Approximating Clustering via the Mountain Method[J].IEEE Trans SMC, 1994;24(8):1279-1284
  • 6Reginald E Hammah ,John H Curran,Validity Measures for the Fuzzy Cluster Analysis of Orientations[J].IEEE Transaction on Pattern Analysis and Machine Intellignce, 2000: 22(12)
  • 7X L Xie,G Beni.A Validity Measure for Fuzzy Clustering[J].IEEE Trans PAMI, 1991; 13(8):841-847
  • 8玄光男 程润伟.遗传算法与工程优化[M].北京:清华大学出版社,2004..
  • 9K Krishna,M Narasimha Murty,Genetie K-Means Algorithm[J].IEEE Transactions on Systems, Man, and Cybernet cs Patr.B : Cybernetics,1999;29(3)
  • 10孙啸,王晔,何农跃,赵雨杰,陆祖宏.生物信息学在基因芯片中的应用[J].生物物理学报,2001,17(1):27-34. 被引量:20

二级参考文献39

  • 1BaldiP BrunakS著 张东晖译.生物信息学-机器学习方法[M].北京:中信出版社,2003.276-279.
  • 2Raychaudhuri S,Chang J T,Imam F,et al. The computational analysis of scientific literature to define and recognize gene expression clusters[J]. Nucleic Acids Research, 2003,15: 4 553~4 560.
  • 3Wicker N,Dembele D,Raffelsberger W,et al. Density of points clustering,application to transcriptomic data anaylsis[J]. Nucleic Acids Research, 2002,(18):3 992~4 000.
  • 4Li Liao,Noble W S. Combining pairwise sequence similarity and support vector machines for remote protein homology detection[J]. Recomb, 2002, (18):255~232.
  • 5Kalton A,Wagstaff K,Yoo J. Generalized clustering,supervised learning, and data assignment [J]. KDD, 2001,(1):299~304.
  • 6Eisen M, Spellman P, Brown P, et al.Cluster analysis and display of genome-wide expression patterns[J].Proc. Natl. Acad Sci. US,1998,(95):14 683~14 688.
  • 7Kohonen T. Self-organizing maps[M]. 3rd ed. Heidelherg: Springer, 2001. 25~40.
  • 8Bickel D R.Robust cluster analysis of microarray gene expression data with the number of clusters determined biologically[J].Bioinformatics,2003,19(7):818~824.
  • 9Somervuo P, Kohonen T. Self-organizing maps and learning vector quantization for feature sequences[J].Neural Processing Letters,1999,10(2):151~159.
  • 10Lukashin AV, Fuchs R. Analysis of temporal gene expression profiles: clustering by simulated annealing and determining the optimal number of clusters[J]. Bioinformatics, 2001, 17: 405-414.

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