糖耐量减低的干预研究

The Intervention Study on Impaired Glucose Tolerance

【目的】探讨吡格列酮单用或联合二甲双胍对糖耐量减低(IGT)的干预效果。【方法】67例IGT患者随机分为两组:单用吡格列酮组(单用组)37例,吡格列酮联合二甲双胍组(联合组)30例。治疗24周,观察两组临床特征的变化及IGT逆转为糖耐量正常(NGT)的有效率。【结果】两组治疗后比较,联合组体重指数(BMI)、空腹血糖(FPG)、糖负荷2 h血糖(2 hPG)、糖化血红蛋白(HbA1C)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)较单用组明显降低,差异有显著性(P<0.05);两组治疗后,腰臀比(WHR)、FPG、2 hPG、HbA1C、TC、TG、LDL-C较治疗前降低,而高密度脂蛋白胆固醇(HDL-C)升高,差异均有显著性(P<0.05),单用组治疗后BMI较治疗前升高(P<0.05);单用组逆转IGT为NGT的有效率21.6%,联合组36.67%,差异有显著性(P<0.05)。【结论】吡格列酮能降低WHR、FPG、2 hPG、HbA1C和调节血脂水平,能逆转IGT至NGT;联合二甲双胍此作用更明显。

[Objective]To investigate the intervention result of pioglitazone alone or in combination with metformin on impaired glucose tolerance （IGT）. [Methods]Sixty Seven cases IGT patients were divided into two groups randomly： pioglitazone alone group 37 cases, pioglitazone combination group 30 cases. After 24 weeks treatment,the change of the clinic characteristics and the efficacy of conversing the IGT to normal glucose tolerance（NGT） were observed. [Results]Comparing with the pioglitazone alone group,the BMI , FPG, 2 hPG, H bA1C, TG, LDL-C（ P〈0.05）were significantly decreased in the combination group after treatment. In both groups, the WHR, FPG, 2 hPG, HbA1C, TC, TG, LDL-C were decreased and the HDL-C were increased more significantly after treatment than before（ P〈0.05） ; the BMI of the pioglitazone alone group was increased after treatment than before（ P〈0.05）. The efficacy rate of conversing the IGT to NGT was 21.6% in the pioglitazone alone group, but the efficacy rate of the combination group was 36.67%, there was significant difference（ P〈0. 05） between two groups. [Conclusion]Pioglitazone can decrease the WHR, FPG, 2hPG, HbA1C, adjust blood lipids level and converse IGT to NGT for IGT patients; the result becomes obvious in combination with metformin.