门静脉高压症患者胃黏膜内皮素受体的基因表达

Expression of Endothelin-1 Receptor A and B in Gastric Mucosa in Portal Hypertensive Gastropathy

【目的】探讨内皮素受体(ETR)亚型基因表达在门静脉高压症胃病(PHG)中的变化及作用。【方法】采用逆转录聚合酶链式反应(RT-PCR)分析42例肝硬化门静脉高压症患者PHG病变部位ETA受体和ETB受体mRNA的变化。【结果】轻度PHG胃黏膜ETAR mRNA、ETBR mRNA表达明显升高,与无PHG组及对照组比较差异均有显著意义(P<0.001),重度PHG的ETAR mRNA、ETBR mRNA表达进一步增强,与轻度PHG者比较差异亦有显著意义(P<0.001);【结论】PHG患者ETR基因过度表达可能是加重胃黏膜损害的重要因素之一。

[Objective]To study the role of the gene expression of ET-1 receptor（ETR） in the development of portal hypertensive gastropathy（PHG）. [Methods] Forty-two portal hypertensive patients were investigated aeeording to with or without PHG, The degree and the loeation of PHG were reeorded. The speeimens were obtained to perform RT-PCR to measure ETAR mRNA and ETBR mRNA. [Results] ETAR mRNA and ET-BR mRNA in severe or moderate PHG with portal hypertension were higher than those in eontrol and in portal hypertension without PHG（ P〈0. 001）. [Conelusion] Portal hypertensive gastrie mueosa may trigger a high eoneentration of ETAR mRNA and ETBR mRNA,ETR may play an important role in further development of PHG.