1Cory S,Huang DCS,Adams JM.The Bcl-2 family:roles in cell survival and oncogenesis[J].Oncogene,2003,22:8590-8607.
2Zong WX.BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak[J].Genes Dev,2001,15:1481-1486.
3Green DR,Kroemer G.The pathophysiology of mitochondrial cell death[J].Science,2004,305:626-629.
4Strasser A.The role of BH3-only proteins in the immune system[J].Nat Rev Immunol,2005,5:189-200.
5Bouillet P,Metcalf D,Huang DCS,et al.Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses,leukocyte homeostasis,and to preclude autoimmunity[J].Science,1999,286:1735-1738.
6Villunger A,Michalak EM,Coultas L,et al.p53-and druginduced apoptotic responses mediated by BH3-only proteins Puma and Noxa[J].Science,2003,302:1036-1038.
7Puthalakath H,Strasser A.Keeping killers on a tight leash:transcriptional and post-translational control of the proapoptotic activity of BH3-only proteins[J].Cell Death Differ,2002,9:505-512.
8Puthalakath H,Huang DCS,O'Reilly LA,et al.The pro-apoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex[J].Mol Cell,1999,3:287-296.
9Puthalakath H,Villunger A,O'Reilly LA,et al.Bmf:a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex,activated by anoikis[J].Science,2001,293:1829-1832.
10Liu X,Dai S,Zhu Y,et al.The structure of a Bcl-xL/Bim fragment complex:Implications for Bim function[J].Immunity,2003,19:341-352.
3Uren R T, Dewson G, Chen L, et al. Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak. J Cell Biol, 2007, 177(2): 277-287.
4Willis S N, Fletcher J I, Kaufiaaann T, et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science, 2007, 315(5813): 856-859.
5O'Reilly L A, Cullen L, Visvader J, et al. The proapoptotic BH3- only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells. Am J Pathol, 2000, 157(2): 449-461.
6O'Connor L, Strasser A, O'Reilly L A, et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. Embo J, 1998, 17(2): 384-395.
7Lei K, Davis R J. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci USA, 2003, 100(5): 2432-2437.
8Putcha G V, Lc S, Frank S, et al. JNK-mediatcd B/M phosphorylation potentiates BAX-dependent apoptosis. Neuron, 2003, 38(6): 899-914.
9Beg A A, Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science, 1996, 274(5288): 782-784.
10Luo J L, Maeda S, Hsu L C, et al. Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell, 2004, 6(3): 297-305.
