环丙氟哌酸等4种抗菌药在家兔组织和血清中的分布

The distribution of ciprofloxacin,cefradine,timentin and gentamicin in rabbits tissues and serum

目的：研究环丙氟哌酸、头孢拉定、特美汀、庆大霉素在家兔骨、软骨、滑膜、韧带、肌肉和血清中的渗透性，为临床合理选用抗菌药、预防和治疗术中感染提供参考依据。方法：新西兰成年家兔４８只，按用药种类分４组，分别于耳静脉推注（１）环丙氟哌酸２００ｍｇ／６０ｋｇ；（２）头孢拉定２．０ｇ／６０ｋｇ；（３）特美汀３．２ｇ／６０ｋｇ；（４）庆大霉素８万ｕ／６０ｋｇ。采用微生物法测定组织中药物浓度。结果：以骨组织为例，４种药物的抗菌浓度排列按以下顺序递减：头孢拉定、庆大霉素、环丙氟哌酸、特美汀。结论：抗菌药物用于各部位感染治疗时，应将药物的组织渗透性、药物浓度、抗菌活性和耐药性等因素综合考虑。头孢拉定、环丙氟哌酸的组织浓度远远大于血清浓度，且抗菌谱广，耐药菌株少，对敏感菌引起的骨及关节组织感染，宜首先考虑应用。

To study the distribution of ciprofloxacin,cefradine,timentin,and gentamicin in rabbit's bone,cartilage,synocium,ligament,muscle,and serum. METHODS:Forty-eight rabbits in 4 groups were intravenously injected respectively ciprofloxacin 200 mg/60 kg,cefradine 2.0g/60 kg,timentin 3.2g/60 kg,and gentamicin 80 000 U/60 kg,RESULTS:In bone issue cephradine has the highest concentration and timentin the lowest.CONCLUSION:Cefradine and ciprofloxacin have better penetrations than others.Using an antibiotic,one should consider its penetration,concentration,activity and side-effects.