慢性前列腺炎病原学病例对照研究

A case-control study of the etiology of chronic prostatitis

探讨慢性前列腺炎（ＣＰ）的病原学机理，对５３例ＣＰ（病例组）和５７例无泌尿生殖系感染的男性（对照组）进行病例对照研究。比较了两组前列腺液解脲支原体、沙眼衣原体、四杯定位细菌培养、前列腺按压液（ＥＰＳ）白细胞计数和前列腺Ｂ超的结果。病例组ＥＰＳ白细胞＞１０００／ｍｍ３的例数高于对照组；病例组金葡菌和大肠杆菌检出率高于对照组，但类白喉杆菌、表皮葡萄球菌和解脲支原体却低于对照组。两组沙眼衣原体检出率无显著性差异。结果可归纳出两条可供参考的结论：①不应将慢性非细菌性前列腺炎作为一种性传播病或顽固性感染告知患者，以免加重患者的精神负担；②只有当患者伴复发性尿路感染时，定位细菌培养法方有较大的实用性。

A control study was made in 53 patients referred for symptoms of chronic prostati tis and 57 asymptomatic men with nO history of genitourinary infection from Ju ne 1993 to June 1994.Both groups were evaluated by prostatic secretion cultures for ureaplasma urealyticum,immunofluorescence for chlamydia trachomatis,4-glass prostatic localization cultures for facultative aerobic bacteria,counts of prostatic fluid leukocytes and prostate ultrasonography.The patients had more than 1000 leukocytes per mm3.in prostatic secretions more often than did controls,A number of organisms were isolated significantly more often from the control populations,including staphylococci and E coli;but controls had significantly more isolates of diphtheroids,staphylococcus epidermidis and U.urealyticum,Chlamydia trachomatis had not significant differences in both groups.Our findings had two important clinical implications:Frist,it was unsuitable to tell men with chronic nonbacterial prostatitis that they have a sexually transmitted disease or a chronic resistant infection.Second,routine prostatic localization studies provided no clinically useful information in most our patients.Therefore,it was suggosted that use of localization studies should be limited to research protocols.