北京地区非妊娠妇女阴道B族链球菌带菌情况的调查

Vaginal Colonization of Group B Streptococcus: A Study in 267 Cases of Factory Women

对北京地区267名女工B族链球菌(GBS)带菌情况进行调查,并探讨其与妇科有关情况的关系。结果表明:GBS带菌率为10.86%。>45岁组带菌率较高,有自然流产史者带菌较多,用宫内节育器避孕者GBS带菌也较不用此法避孕者为多,但均无明显统计学差异。调查组未见用避孕药者GBS带菌增多,亦未见有卵巢囊肿与子宫肌瘤病史者GBS阳性明显增多。阴道、宫颈与附件有炎症表现者GBS阳性为多,尤以阴道与宫颈炎症者为明显,统计学差异有非常显著性。所分离的GBS菌株作菌型鉴定,其中主要菌型为Ⅱ型与Ⅲ型,各占31%。抗生素敏感试验结果表明,分离的GBS菌株对青霉素和较新使用的头孢菌素基本敏感,而对丁胺卡那霉素和苯唑青霉素耐药菌株高达一半以上。

An epidemiologic study on vaginal colonization of group B streptococcus (GBS) from non—pregnancy women was carried out. Two hundreud sixty seven female workers were studied. The carrier rate of GBS in vaginal specimens was 10.86%. Women aged 45 years old and above had more cases with genital tract GBS colonization. Women with vaginal colonization had more history of miscarriage and using IUD. We did not find the positive correlations between vaginal colonization and oral contraceptive, ovarian cyst ; hysteromyoma in our study group. Women with gynecologic inflammation had more cases with vaginal GBS colonization. There is a significant increase for women with vaginitis and cervicitis. Serotyping study showed that types Ⅲ and Ⅱ were the most frequent GBS types isolated from the carriers. Antibiotic sensitivity test showed that more than half GBS strains were resistant to oxcillin and amikacin.