儿童幽门螺杆菌感染血清学研究

A Serological Study on the Infection of Helicobacter pylori among Children

应用ELISA法对181份反复中上腹及脐周痛患儿血清及192份对照血清进行了抗幽门螺杆菌(Helicobacter pylori,Hp)IgG、IgM测定。结果表明:有上述症状患儿血清抗-Hp IgG检出率(53%)明显高于其他对照组(34.6%～35%),可作为Hp感染的辅助诊断指标,但其滴度与病程长短及病情严重程度无明显关系,不能反映现症感染。儿童抗-Hp IgG检出率随年龄增加而上升,大年龄组儿童抗-Hp IgG检出率与成人者相近。儿童血清抗-Hp IgM水平与Hp感染无明显关系。

Using ELISA method,anti—H. pylon IgG and IgM were detected in 181 sera from patients (aged 2—14 years) complaining of repeated midepigastical pain and 152 sera of controls. The positive rate of anti-H. pylori IgG in the patients was 53%, significantly higher than those of control groups (34.6%—35%), (P<0.05). The presence of anti-H, pylori IgG in serum can assist in the diagnosis of H. pylori, but can not indicate the existence of H. pylori. There were no evident relationships between level of antibodies (anti—H. pylon IgG and IgM) and the degree of H. pylori infection, or the duration of disease. Children's H. pylori infection increases with age. Elder children have the same positive rate of anti—H, pylori IgG as adults. Hence, eradication of H. pylori infection should be focused not only on adults but also on childern.