可乐定对兔利多卡因硬膜外麻醉效果及药物浓度影响的实验研究

Effects of Clonidine on Lidocaine Epidural Anesthesia and Its Serum Concentration in Rabbits

本文评价了兔利多卡因硬膜外麻醉时,可乐定对阻滞效果和利多卡因血药浓度的影响。18只白兔随机分为利多卡因对照组(1组)、肾上腺素组(2组)和可乐定组(3组)。采用盲法硬膜外分别注射上述三组药物。结果显示,可乐定能延长感觉和运动阻滞时间,降低血清利多卡因水平。其作用类似于肾上腺素,可能是可乐定通过作用于脊髓肾上腺素能受体发挥镇痛效应和/或发挥α_2受体介导的缩血管作用。

This study examined the effects of clonidine on lidocaine serum concentration and anesthetic effect after lido-caine-clonidine epidural administration in rabbits. Eighteen rabbits were randomly allocated into three groups, Group 1 (n = 6),lidocaine control) group 2(n=6), lidocaine plus epinephrine and group 3(n = 6) ,lidocaine plus clonidine. The results reveal that clonidine prolonged the duration of lidocaine action and decreased lidocaine serum level similar to epinephrine. It is supposed that clonidine might exert the effect mentioned above through the activation of the adrenergic receptors in the spinal cord and/or the action of alpha2 adrenoceptor-mediated vasoconstric-tion.