慢性颅内高压病人麻醉中血清TSH PRL GH及皮质醇的变化

Changes of Serun TSH, GH and Cortisol Levels in the Patients with Chronic Intracranial Hypertension during Anesthesia

65例非垂体瘤择期开颅病人:40例慢性颅内高压(CICHT)病人,25例正常颅压(NICP)病人。用放免法测定这些病人麻醉前、插管后1min、开颅中及病灶清除时血清TSH、PRL、GH和皮质醇水平的变化。结果:(1)麻醉前CICHT组血清皮质醇水平显著低于NICP组(P<0.01)。(2)插管后及术中,CICHT组血清TSH、PRL、GH及皮质醇水平显著低于NICP组(P<0.05～0.01)。结果表明,CICHT病人垂体内分泌功能降低。

65 patients with non-pituitary tumors were scheduled for craniotomy. 40 patients with chronic intracranial hypertension (CICHT); 25 patients with normal intracranial pressure (NICP). Blood samples for radioimmunoassay measurement of serum TSH, PRL, GH and cortisol concentrations were taken prior to anesthesia, 1 min after intubation, during craniotomy and immediately after removing focuses. Result : (1) Preanesthesia serum cortisol values in the group CICHT were significantly lower(P<0. 01) than those in the group NICP. (2) Postintubation and intraoperation serum TSH, PRL, GH and cortisol values in the group CICHT were significantly lower(P< 0. 05-0. 01) than those in the group NICP. The results reveal that the pituitary functions are decreased in the patients with CICHT.