摘要
应用２４５０ＭＨｚＣＷ微波，以不同剂量、不同时段辐照荷瘤鼠，观察微波对ＴＩＬ细胞及其亚群和ＩＬ－２Ｒα作用。结果发现：不同的微波辐照剂量，其对抗肿瘤免疫作用不尽相同。０．２ｍｗ·ｃｍ－２微波辐照，属非热效应的剂量，对抗肿瘤免疫无明显作用；２ｍｗ·ｃｍ－２微波辐照，可使抗肿瘤免疫滞后增强；２０ｍｗ·ｃｍ－２微波辐照，对肿瘤细胞具杀伤作用，但连续辐照８ｄ以上时，则出现抗肿瘤免疫的抑制，提示微波应用于肿瘤治疗时，采用２０ｍｗ·ｃｍ－２微波定量辐照应少于８ｄ。
In this article,we studied anti-tumor immunofunction(TIL,T:subsets and IL-2R) changes through 2450 MHzCW microwave irradiation on tumor bearing mice in 4,8 and 12 days with different doses,50min/day.The results showed that different microwave radiation dose had different effects on anti-tumor immuneoresponse,0.2mw·cm-2 microwave radiation had little influence on anti-tumor immune function;2mw·cm-2,anti-tumor immune was delayed excited;20mw·m-2,could inhibite tumor grow,but when radiation time>8 days,anti-tumor immunication was supressed.This suggested that in clinical treatment of tumor with 20mw·cm-2microwave the irradiation time could shorter than 8 days.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1996年第1期35-38,共4页
Immunological Journal
