羟丙基甲基纤维素在凝胶骨架中的含量与水溶性药物释放机制的关系

MECHANISM OF SOLUBLE DRUG RELEASE FROM HYDROPHILIC MATRICES,THE EFFECT OF HYDROXYPROPYLMETHYLCELLULOSE CONTENT

研究了羟丙基甲基纤维素（ＨＰＭＣ）在亲水凝胶骨架中的含量对水溶性药物释放机制的影响。本研究以水溶性药物卡托普利和硫酸沙丁胺醇为模型药物，通过对Ｐｅｐｐａｓ方程中ｎ值的讨论，证实水溶性药物从凝胶骨架中释放的机制为非Ｆｉｃｋ扩散。结果认为３０％以上的ＨＰＭＣ构成的凝胶骨架才能阻滞水溶性药物的释放。随着骨架中ＨＰＭＣ含量的增加，药物释放逐渐减慢。骨架中ＨＰＭＣ含量的不同将使药物释放后期偏离Ｈｉｇｕｃｈｉ线性方程，但不影响水溶性药物释放机制。

The effect of hydroxypropylmethylcellulose(HPMC)content on mechanism ofsol uble drug release from hydrophilic ma trix tablets was studied.Captopril and salbutamol sulphatewere chosen as model drugs.The study confirmed that soluble drugs were released by non-Fickiandiffusion mechanism by evaluating the n value in Peppas equation,The 30%of HPMC content wasregarded as the minimum content,at which dose the release of soluble drugs could be retarded。Different contents of HPMC in matrix only affected the Higuchi release patterns of soluble drugs afterabout 80%of the total drugs were released but did not change their release mechanism。