短期强磁场暴露对金黄地鼠视网膜内多巴胺含量的影响

Changes of retinal dopamine levels after expose to short-term strong magnetic field in hamsters

目的研究0．1 Hz极低频交变磁场全身暴露对金黄地鼠眼视网膜内多巴胺含量的影响。方法36只成熟雄性金黄地鼠随机分为4组,每组9只,1组为对照组,另3组分别全身间断暴露于50、 75、100 mT交变磁场7 d,每天暴露8 h,然后测定视网膜内神经递质多巴胺含量。结果场强在50 mT 时,地鼠视网膜内多巴胺含量变化无统计学意义(P>0．05),而在75、100 mT时地鼠视网膜内多巴胺含量增加有统计学意义(P<0．01)。100 mT比75 mT时地鼠视网膜内多巴胺含量增加有统计学意义(P< 0．05)。结论全身暴露磁场强度到达一定水平时可刺激金黄地鼠视网膜内多巴胺的合成和分泌,强度越强作用越明显,若长期的强磁场暴露将可能因视网膜内多巴胺含量的变化而影响视网膜的功能。

Objective To study changes of retinal dopamine levels after exposure to 0.1 Hz extreme low frequency alternative magnetic field in hamsters. Methods 36 male golden hamsters were randomly sorted into 4 groups. Whole body of the experimental animals were exposed to 50,75,100 mT alternative magnetic field intermittently for 8 hours per day for continuous 7 days, and then the retinal dopamine levels were analysed. Results The contents of retinal dopamine were significantly increased in the 75 mT and 100 mT exposure groups,but was not significantly changed in the 50 mT group. Conclusions Whole body exposure to magnetic field could increase the synthesis and secretion of retinal dopamine in hamsters when the magnetic field reached to a certain intensity, and these effects increased gradually with the increase of field intensity. Exposure to long-term strong magnetic field may change the retinal functions because of the increase of retinal dopamine levels.