高压氧综合治疗早期新生儿缺氧缺血性脑病疗效分析

Therapeutic effects of HBO in treating hypoxic-ischemic encephalopathy in newborn babies

目的探讨应用高压氧综合治疗早期新生儿缺氧缺血性脑病(HIE)的疗效及预后。方法将73例中、重度早期HIE新生儿进行高压氧综合治疗作为治疗组,将68例中、重度早期HIE患儿应用常规治疗作为对照组。所有病例均于出生后3、6、12、18个月龄进行检测。结果治疗组中,患儿在 12-14 d NBNA评分、在3、6、12、18个月龄时的发育商(DQ)值和预后不良的发生率与对照组比较,差异有显著性意义(P<0．05)。结论应用高压氧综合治疗早期新生儿HIE疗效显著,对预后情况有明显的改善。

Objective To study the therapeatic effects of HBO in treating hypoxic-ischemic encephalopathy （HIE） in newborn babies. Methods 141 newbron babies with HIE were randomized into two groups ： the HBO group （73 cases, babies with severe HIE） were treated by HBO, and the normal control group （68 cases） were treated in the normal way. At 3,6, 12,18 months follow-up visits, all the patients were measured by Gesell Scale-R revised by Capital Pediatrics Research Institute. Results The NBNA scoring at 12～14 days, the developmental quotient （DQ） at 3,6,12,18 month and the rate of unfavourable prognosis in the HBO group were significantly higher than those in the control group （ P 〈 0.05 ）. Conduslons HBO had significant therapeutic effects on newborn babies with HIE.