吡拉西坦拮抗地西泮对小鼠致健忘作用

ANTAGONISM OF PIRACETAM ON THE AMNESTIC EFFECT OF DIAZEPAM IN MICE

用小鼠跳台法，于训练前１ｈ先ｐｏ地西泮１ｍｇ·ｋｇ￣（－１），对小鼠记忆获得有明显损害作用；而于训练前１ｈｉｐ吡拉西坦２００ｍｇ·ｋｇ￣（－１），对地西洋造成的记忆获得不良则有明显改善作用。此结果在避暗法中得到验证。另采用光电管法，吡拉西但对地西泮的中枢抑制作用没有显著性影响。用ｙ迷宫法，于训练前３ｍｉｎ先ｉｃｖ谷氨酸０．１μｇ，则能显著提高小鼠的空间学习成绩，并能完全对抗ＧＡＢＡ造成的记忆缺损。

In step-down test,diazepam(1 mg·kg￣(-1) po,1h before training)was shown tosignificantly impair memory acquisition in mice.But piracetam(200 mg·kg￣(-1) ip,1 h beforetraining)was found to improve the diazepam-induced impairments of learning.By photocell cagemethod,piracetam showed no significant inhibitory effect on the diazepam-induced spontaneous motoractivity in mice.In Y-maze test,Glutamic acid(0.1 μg,icv,3 min before training)significantlyimproved learning in normal mice and the amnesic effect of G ABA and diazepam were completelyantagonized by Glutamic acid and piracetam(200 mg·kg￣(-1) ip,1h before training). These resultSsuggest that increasing GABA-ergic neuronal transmission is unfavorable to learning and memory,butincreasing Glu-ergic transmission is contrary to the former.It seemed that the presence of Glu/GABAsystem in the brain could regulate learning and memory.