PLA2G4A基因多态性与精神分裂症的关系

Association between PLA2G4A gene polymorphism and schizophrenia

目的:探讨1号染色体上PLA2G4A基因多态性与中国北方汉族人群精神分裂症的关系。方法:采用聚合酶链式反应-限制性内切酶片段长度多态性(PCR-RFLP)的方法,对235个由精神分裂症患者及其健康父母双亲组成的核心家系进行PLA2G4A基因型检测,应用SPSS12.0统计学软件进行数据管理及数据分析。结果:患者组和父母组中基因型频率分布均符合Hardy-Weinberg平衡定律(P>0.05);单倍型相对风险分析(HRR)结果显示,传递和未传递的等位基因A、G的频数分布病例组与对照组比较差异无显著性(P>0.05);传递不平衡检验(TDT)分析结果表明,杂合子父母双亲的两个不同等位基因传递概率未偏离50%(P>0.05)。结论:1号染色体上的PLA2G4A基因可能不是精神分裂症的易感基因。

Objectfve To investigate the genetic association between polymorphism of PLA2G4A gene in chromosome 1 and schizophrenia in the Han people of Northern China. Methods The method of PCR-RFLP was conducted to examine the genotypes of PLA2G4A gene in samples of 235 Chinese Han family trios consisting of fathers, mothers and affected offsprings with schizophrenia. Then the analysis of haplotype relative risk （HRR） and transmission disequilibrium test （TDT） were used to deal with the data statistically. Results The genotypic frequency of PLA2G4A gene did not deviate from Hardy-Weinberg equilibrium in both case and control groups （P〉0.05）; HRR analysis did not show a significant difference in the allelic （A and G） frequency of PLA2G4A gene between transmit and untransmit （P〉0.05）; TDT analysis suggested that the possibility of the two different alleles transmitted from the heterozygotic parents didn＇t deviate from 50%（P〉0.05）. Conclusfon The PLA2G4A gene in chromosome 1 may be not the susceptible gene of schizophrenia.