C-erbB-2、Nm23和MDR1基因在原发性乳腺癌中的表达及与转移和预后的相关性

Expressions of C-erbB-2,Nm23 and MDR1 in primary breast cancer and their relations with metastasis and prognosis

目的:探讨C-erbB-2、Nm23和MDR1在原发性乳腺癌中的表达及其与转移和预后的关系。方法:采用免疫组化法(S-P法)检测49例乳腺癌患者手术切除组织中C-erbB-2、Nm23和MDR1的表达,并分析3种基因之间的相关性及其与转移的关系。结果:49例乳腺癌患者中C-erbB-2、MDR1高表达和Nm23低表达的患者转移发生率高(P<0.05)。MDR1的表达与C-erbB-2的表达有相关性(rs=1.00,P<0.05),Nm23与C-erbB-2的表达无相关性(rs=0.80,P>0.05),MDR1的表达与Nm23的表达无相关性(rs=0.80,P>0.05)。C-erbB-2、MDR1同时阳性的患者及C-erbB-2阳性、Nm23阴性的患者转移发生的几率较高,预后较差。结论:C-erbB-2、Nm23和MDR1与乳腺癌转移有关,多个指标联合检测用来估计患者预后指导意义更佳。

Objective To investigate the expressions of C-erbB-2, Nm23 and MDR1 in primary breast cancer and their relations with metastasis and prognosis. Methods Immunohistochemieal method （S-P method） was used to deteet C-erbB-2, Nm23, MDR1 expressions in 49 patients with primary breast eaneer. The eorrelations between the three genes and their relations with metastasis and prognosis were analysed. Results The metastasis rate was higher in patients with high-expressions of C-erbB-2, MDR1 and low-expression of Nm23 （P〈 0.05）. The expressions of C-erbB-2 and MDR1 had eorrelation （rs = 1.00, P〈0.05）. The expression of C-erbB-2 and Nm23 had no eorrelation （rs=0.80, P〉0.05）. The expression of MDR1 and Nm23 had no eorrelation （rs=0.80, P〉 0.05）. The metastasis rate in patients with both C-erbB-2 （＋） and MDR1 （＋） was higher than the others. Their prognosis was negative. The metastasis rate in patients with both GerbB-2 （＋） and Nm23 （-） was higher than the others. Conclusion There are correlation between C-erbB-2, Nm23, MDR1 expressions and metastasis of breast cancer. Multi-predictors are better guide to patients than single predictor.