胎膜早破孕妇血清中IL-8水平与绒毛膜羊膜炎的关系

Relationship between maternal serum Interleukin-8 and chorioamnionitis in patients with PROM

[目的]探讨胎膜早破孕妇血清中IL-8的含量与绒毛膜羊膜炎的关系。[方法]采用放射免疫法对45例胎膜早破和30例正常足月孕妇血清中IL-8浓度进行测定,同时胎膜行病理检查。[结果]胎膜早破孕妇血清中IL-8的水平随破膜时间的延长而升高;胎膜早破组血清中IL-8的水平为(824.04±341.28)pg/mL,其水平明显高于对照组,两组比较,差异有统计学意义(P<0.05);胎膜早破中绒毛膜羊膜炎患者血清中IL-8的水平为(985.50±422.15)pg/mL,其水平明显高于非绒毛膜羊膜炎患者,两组比较,差异有统计学意义(P<0.05);轻度、中、重度绒毛膜羊膜炎组孕妇血清中IL-8的水平分别为(912.35±321.00)、(1568.46±789.68)2、612.67 pg/mL,与非绒膜羊膜炎组相比均有显著性差异(P<0.05)。[结论]母血中IL-8水平可作为足月胎膜早破组织绒毛膜羊膜炎的一个预测指标。

[ Objective] To study the relationship of materal serum interleukin- 8（ IL - 8） concentration in patients with premature rupture of membranes （PROM） for chorioamnionitis. [ Methods] Maternal serum IL - 8 were measured by radioimmunoassay in 45 case of pregnant women with PROM and 30 case＇ of normal pregnant women . Chorioamnionitis was histopathologically confirmed after delivery. [ Resullts] The longer the duration from rupture of membranes of delivery was, the more serious chorioamnionitis was, and the higher the levels of IL - 8 in maternal serum; The levels of IL - 8 in materal serum were （824.04 ± 341.28） pg/mL, significantly higher in patients with PROM than those of the control group （P 〈 0.05）; The levels of IL- 8 in materal serum were （985.50 ± 422.15） pg/mL, significantly higher in patients with chorioamnionitis than those of the non - chorioamnionitis （ P 〈 0.05） ; The serum of materal IL - 8 with histological chorioamnionits showed a significantly higher than those without chorioamnitis（ P 〈 0.05）, The levels of IL - 8 in materal serum were（912.35 ± 321.00）, （ 1568.46 ±789.68）, （2612.67） pg/mL. [ Conclusion] Measurement of materal serum IL - 8 is a marker for screening histological chorioamnionits PROM .