氯沙坦和氨氯地平对高血压病患者血压、血尿酸的作用比较

Comparison of effect of losartan on blood pressure and uric acid with amlodipine in patients with hypertesion

[目的]比较氯沙坦和氨氯地平的降压疗效和对血尿酸的影响。[方法]选择大连医科大学第二临床学院北院心内科住院的高血压病人98例,随机分为两组:A组49例,晨服单一药氯沙坦50 mg/d;B组49例,晨服单一药氨氯地平5 mg/d,观察8周。治疗前后测血压、血尿酸。[结果]与用药前比较,服药8周后,两组血压均显著下降(P<0.01),组间无差异(P>0.05);两组血尿酸均下降,与用药前比较,氯沙坦组下降显著(P<0.05),氨氯地平组下降无显著性(P>0.05)。[结论]氯沙坦与氨氯地平降压疗效相似,均可作为抗高血压一线用药。其中,氯沙坦对高尿酸血症的患者尤为首选。

[ Objective] Comparison of the effect of losartan on blood pressure and uric acid with amlodipine. [ Methods] Ninty- eight aged patients with hypertension were randomly divided into group A and group B. The patients of group A received losartan 50mg qd; the patients of group B received amlodipine 5mg qd. The time of treatment was 8 weeks. Blood pressure was measured every other week. The changes of blood pressure and the serum uric acid in the end of week 8 were measured. [ Results] The blood pressure were significantly decreased on week 8 in group A and group B （P 〈 0.01 ）, and the decrease in diastolic pressure and systolic pressure in group A and group B did not differ significantly （ P 〉 0.05）. While hyperuricemia were significantly decreased in losartan group （ P 〈 0.05）; Serum uric acid was not changed in amlodipine group （P 〉 0.05）. [Conclusion] Losartan has the same effect of decreasing blood pressure with amlodipine, but losartan also decreases serum uric acid besides decreasing bloodpressure. For the patient with hypertension compamied by hyperuricemia , losarten is the first choice of decreasing blood pressure.