摘要
[目的]观察芬太尼透皮贴剂(多瑞吉)对晚期癌症伴中、重度疼痛患者的镇痛效果及不良反应。[方法]对67例患者给予芬太尼透皮贴镇痛治疗:初始剂量25~50μg/h,最大为300μg/h。[结果]治疗前疼痛程度评分均值为7.42±1.42,治疗后为1.73±1.21,疼痛程度显著减轻(P〈0.01),总有效率92.54%,其中中度缓解率16.42%,明显缓解率47.76%,完全缓解率28.36%。副作用少且较轻微,治疗后患者的生活质量明显改善(P〈0.05)。[结论]芬太尼透皮贴可有效控癌性疼痛,副作用少,值得大力推广。
[ Objective] To evaluate the efficacy and safety of transdermal fentanyl in treatment of middle to severe cancer pain. [ Method] Ahogether 67 patients were treated with one transderrnal fentanyi. The initial dose was 25 - 50 μg/h and the maximal dose being 300 μg/h. [ Results] Baseline mean pain intensity was 7.42 ± 1.42, the mean scores of pain were decreased to 1.73 ± 1.21 after treatment, respectively( P 〈 0.01 ). The total remission rate of pain were 92.54%, the moderate, effective and excellent rates were 16.42 %, 47.76 % and 28.36 %. The quality of life was significantly improved after treat ment ( P 〈 0.05). It had few and slight side- effects. [Conclusion] Transdermal fentanyi is effective in relieving cancer pain with slight side- effects and can be populized clinically.
出处
《大连医科大学学报》
CAS
2006年第3期224-225,共2页
Journal of Dalian Medical University