芬太尼透皮贴剂治疗癌痛的临床观察

Clinical evaluation of transdermal fentanyl in treatment of cancer pain

[目的]观察芬太尼透皮贴剂（多瑞吉）对晚期癌症伴中、重度疼痛患者的镇痛效果及不良反应。[方法]对67例患者给予芬太尼透皮贴镇痛治疗：初始剂量25～50μg／h，最大为300μg／h。[结果]治疗前疼痛程度评分均值为7．42±1．42，治疗后为1．73±1．21，疼痛程度显著减轻（P〈0．01），总有效率92．54％，其中中度缓解率16．42％，明显缓解率47．76％，完全缓解率28．36％。副作用少且较轻微，治疗后患者的生活质量明显改善（P〈0．05）。[结论]芬太尼透皮贴可有效控癌性疼痛，副作用少，值得大力推广。

[ Objective] To evaluate the efficacy and safety of transdermal fentanyl in treatment of middle to severe cancer pain. [ Method] Ahogether 67 patients were treated with one transderrnal fentanyi. The initial dose was 25 - 50 μg/h and the maximal dose being 300 μg/h. [ Results] Baseline mean pain intensity was 7.42 ± 1.42, the mean scores of pain were decreased to 1.73 ± 1.21 after treatment, respectively（ P 〈 0.01 ）. The total remission rate of pain were 92.54%, the moderate, effective and excellent rates were 16.42 %, 47.76 % and 28.36 %. The quality of life was significantly improved after treat ment （ P 〈 0.05）. It had few and slight side- effects. [Conclusion] Transdermal fentanyi is effective in relieving cancer pain with slight side- effects and can be populized clinically.