高纯度戊唑醇的合成与表征

Synthesis and characterization of high purity tebuconazole

以对氯苯甲醛为原料,经缩合、加氢、环氧化、开环合成高纯度杀菌剂戊唑醇。此工艺选择了一种新颖的催化剂避免了副产物-4,4-二甲基-3-(4H-1,2,4-三唑-4-基甲基)-1-(4-氯苯基)-3-戊醇的产生,戊唑醇总收率≥65%,不需重结晶产品纯度≥98.0%。各项经济技术指标均超过文献水平,已工业化生产。

Using 4-chlorophenylaldehyde as the starting material, tebuconazole was synthesized by condensation, hydrogenation, epoxidation, and ring-opening. A new catalyst was used to avoid production of the byproduct, 4,4- dimethy1-3-（4H-1,2,4-triazole-4-ylmethy1）-1-（4-chlorophenyl）-3-pentanol. Overall yield was over 65%, and purity was over 98.0% without requiring recrystallization. Economic and technical indices of this synthetic method are more favorable than those previously reported, and the method has already been commercialized.