冠脉内支架植入术及联合抗凝治疗急性心肌梗死的临床研究

Clinical Study of Introcoronary Stent Implantation with Associated Anticoagulation Therapy in Acute Myocardial Infarction.

目的探讨冠脉内支架植入术及联合抗凝治疗急性心肌梗死的临床效果。方法自2001年3月至2003年10月在我院就诊的急性心肌梗死病人156例,随机分为治疗组79例(男62例,女17例),给予冠脉内支架植入及联合抗凝治疗;对照组77例(男59例,女18例),给予静脉溶栓。所有病人均行冠脉造影,进行两组间比较。结果治疗组在冠脉再通率、恢复TIMI3级血流、心功能改善方面显著优于对照组(P<0.01);而大出血、病死率明显低于对照组(P<0.05)。结论冠脉内支架植入术及联合抗凝治疗急性心肌梗死是有效、安全的,可减少并发症的发生。

Objective To evaluate the clinical effect of introcoronary stent implantation with associated anticoagulation therapy in acute myocardial infarction （AMI）. Methods From March 2001 through October 2003, consecutive 156 patients with AMI in our hospital were randomized to therapy and control groups. Therapy group including 79 patients （62 men, 17 women） were treated with introcoronary stent implantation with associated anticoagulation; control group including 77 patients （59 men, 18 women） were treated with intravenous thrombolysis. All patients had selective coronary angiography. We had comparison study between two groups. Results Compared with control group, therapy group increased coronary repatency, restoration of TIMI Iii blood flow and cardiac function improvement significantly （P〈0.01）, and reduced large hemorrhage incidence, mortality significantly （P〈0.05）. Conclusions Primary stent implantation with associated anticoagulation therapy is effective and safe, it can reduce complications incidence.