CD147和VEGF蛋白在食管鳞状细胞癌中的表达及意义

The Significance of CD147 and VEGF Expression in Esophageal Squamous Cell Carcinoma

目的探讨食管鳞状细胞癌中CD147和VEGF蛋白的表达及意义。方法应用免疫组化S-P法观察70例食管鳞癌组织中CD147和VEGF蛋白的表达。结果在低分化、中分化和高分化食管鳞癌组织中CD147蛋白的阳性率分别为87.50%、96.43%和96.15%,VEGF蛋白的阳性率分别为87.50%、92.86%和88.46%。CD147和VEGF蛋白的表达均与食管鳞癌浸润深度有关,与分化程度及临床分期无明显关联;有淋巴结转移的病例阳性率明显高于无淋巴结转移组。结论CD147和VEGF蛋白的表达均与食管鳞癌的浸润深度、淋巴结转移有关。

Objective To investigate the significance of CD147 and VEGF expression in esophageal squamous cell carcinoma. Methods The protein expression of CD147 and VEGF in 70 cases with esophageal squamous cell carcinoma were determined by immunohistochemical streptavidinperoxidase method. Results In the poor - differentiated, middle - differentiated and well - differentiated esophageal squamous cell carcinoma, the positive rate of CD147 were 87.50%, 96.43%, 96. 15% , and the positive rate of VEGF were 87.50%, 92. 86%, 88. 46%. The expression of CD147 and VEGF had a significant relevance to infiltrating depth and lymph node metastasis, but no association was observed with pathological grades. Conclusions Both CD147 and VEGF have relevance to infiltrating depth and lymph node metastasis and clinical staging of esophageal squamous cell carcinoma.