摘要
RNA干扰(RNAinterference,RNAi)是通过导入与靶基因序列同源的双链RNA(dsRNA)诱导的序列特异性的转录后基因沉默现象(posttranscriptionalgenesilencing,PTGS)。目前,RNA的作用机制已经基本明确,并显示出广阔的应用前景。作者主要从癌症、病毒和细菌性疾病、寄生虫病、呼吸道疾病和神经性疾病几个方面综述RNAi在基因治疗上的研究新进展。
RNA interference （RNAi） induce a special post-transcriptional gene silencing（PTGS） by introducing a doublestranded RNA（dsRNA） which homology to the target gene. At present,the mechanism of RNAi has been understangded and has shown a widely application prospect. This review manly summarizes RNA interference＇s new research progress in gene therapy from the aspects of cancers, viruses and,bacteria diseases, parasites diseases , respiratory diseases and neurological diseases.
出处
《中国畜牧兽医》
CAS
2006年第5期31-35,共5页
China Animal Husbandry & Veterinary Medicine
