冠心病血瘀证血管内皮细胞功能的检测分析

Analysis of the Function of Vascular Endothelial Cells in Coronary Heart Disease Patients of Blood-Stasis Syndrome

目的探讨血管内皮细胞功能在冠心病(coronary heart disease,CHD)心血瘀阻证中的作用。方法对冠心病心血瘀阻证组112例、冠心病非心血瘀阻证组108例、非冠心病心血瘀阻证组110例和健康人对照组100名检测分析血管内皮细胞产生的一氧化氮(NO)、内皮素(ET)、血管紧张素Ⅱ(AgⅡ)、可溶性细胞间黏附分子(sICAM-1)和可溶性血管细胞黏附分子(sVCAM-1)等血管活性物质。结果ET、AgⅡ、sICAM-1和sVCAM-1的异常程度均呈CHD心血瘀阻证组>CHD非血瘀证组>健康人对照组的趋势(P<0·05或P<0·01);而CHD心血瘀阻证组和非冠心病心血瘀阻证组之间差异无显著性(P>0·05)。结论血管内皮细胞分泌的ET、AgⅡ、sICAM-1和sVCAM-1等血管活性物质,与CHD形成及病情变化密切相关,可能是CHD“血瘀”病理重要标志物。

Objective To explore the function of vascular endothelial cell （VEC） in patients with coronary heart disease （CHD） of Xin-blood-stasis syndrome, Methods Some vasoactive substances produced by VEC were detected and analyzed in patients with CHD of or without Xin blood stasis syndrome in group A （n = 112） and group B （n = 108） respectively, also in patients with non-CHD but of Xin-blood-stasis syndrome in group C （n = 110）, and healthy persons in group D （n = 100）, including nitric oxide （NO）, endothelin （ET）, angiotensin Ⅱ （Ag Ⅱ ）, soluble intercellular adhesion molecule-1 （sICAM-1） and soluble vascular cell adhesion molecule -1 （sVCAM-1）. Results The abnormality degree of ET, Ag Ⅱ , sICAM-1 and sVCAM-1 in various groups showed such a tendency as group A〉 group B〉 group D （P〈0.01 or P〈0.05）, while no significant difference in these criteria between group A and group C was shown （P 〉 0.05）. Conclusion The vasoactive substances secreted by VEC are closely related to the formation and progression of CHD, and are likely to be important pathological markers of blood-stasis syndrome in CHD.