复方苦参联合放化疗治疗恶性肿瘤

Clinical Observation of the Treatment of Malignant Tumor by Radiochemotherapy Combined with Composite Kusheng Injection

目的:回顾性分析复方苦参注射液联合放化疗治疗恶性肿瘤的临床疗效和不良反应。方法:选取同期住院的恶性肿瘤患者69例,分为治疗组35例和对照组34例。两组均采用放化疗综合治疗,治疗组在常规化疗或放疗基础上予复方苦参注射液。比较两组近期疗效、胃肠道反应、白细胞计数及血转氨酶水平等指标的差异。结果:治疗组完全缓解(CR)14例,部分缓解(PR)7例,稳定(NC)10例,恶化(PD)4例。对照组CR13例,PR7例,NC9例,PD5例,总有效率58.8%,两组疗效无统计学差异(P=0.980)。治疗组胃肠道反应、白细胞降低及转氨酶升高等不良反应发生率比对照组低(P<0.05)。结论:联合复方苦参虽未能提高放化疗的近期疗效,但能明显减轻放化疗的不良反应。

OBJECTIVE：To retrospectively analyze clinical curative effect and side effects of treating malignant tumor by radiochemotherapy combined with composite kusheng injection. METHODS： 69 cases of malignant tumor hospitalized at the same period were divided into treatment group （35 cases ）and control group （34 cases ）. Two groups all accepted radiochemotherapy, but in addition, treatment group was also treated with composite kusheng injection. The differences between 2 groups in short-term curative effects, gastrointestinal tract reaction, leukocyte count and the value of serum transaminase were compared. RESULTS： Complete remission（CR）in treatment group was in 14 cases, partial remission （PR） was in 7 cases, no change was in 10 cases and progression of disease （PD）was in 4 cases. CR in control group was in 13 cases, PR was in 7 cases, NC was in 9 cases and PD statistical difference between two groups （ P = 0. 980 ）. was in 5 cases. Total effective rate was 58.8%, there was no The incidence of Gastrointestinal tract reaction , reduction of leukocyte and the rise of serum transaminase in treatment group was lower than that in control group （P 〈 0.05）. CONCLUSION： Although combined use of composite kusheng injection can not improve short-term curative effect of radiochemotherapy, it can obviously alleviate side effects caused by radiochemotherapy.