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细胞色素P450相关基因表达下调与原发性肝癌的发生发展有关 被引量:2

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摘要 目前肝细胞癌(HCC)是全球死亡率居第三位的恶性肿瘤,其病因比较明确,临床研究进展很快,但复发率仍较高.研究一系列肝癌预后分子标志物,可及早预测癌细胞转移,阻止肿瘤生长,判定患者预后,最终达到满意控制肿瘤的目的.
出处 《中华消化杂志》 CAS CSCD 北大核心 2006年第4期274-275,共2页 Chinese Journal of Digestion
基金 江苏省"135"工程重点课题资助项目
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参考文献4

  • 1Suriawinata A,Xu R.An update on the molecular genetics of hepatocellular carcinoma.Semin Liver Dis,2004,24:77-88.
  • 2Agundez JA.Cytochrome P450 gene polymorphism and cancer.Curr Drug Metab,2004,5:211-224.
  • 3Agundez J A,Ledesma MC,Benitez J,et al.CYP2D6 genes and risk of liver cancer.Lancet,1995,345:830-831.
  • 4Brennan P.Gene-environment interaction and aetiology of cancer:what does it mean and how can we measure it.Carcinogenesis,2002,23:381-387.

同被引文献18

  • 1施瑞华,王伟,于莲珍,黄霞月,陈子庆,赵志泉.细胞色素P450 2E1基因多态性与食管癌的易感性[J].中华内科杂志,2005,44(5):388-389. 被引量:4
  • 2周小华,韩晓.AhR途径,CYP1A1、CYP1B1,雌激素代谢及作用过程中的调节[J].医学分子生物学杂志,2005,2(3):236-239. 被引量:8
  • 3赵伟红,焦效兰.细胞色素P450基因多态性与肿瘤易感性的关系[J].医学理论与实践,2005,18(8):869-871. 被引量:3
  • 4李连弟,鲁凤珠,张思维,牧人,孙秀娣,皇甫小梅,孙杰,周有尚,欧阳宁慧,饶克勤,陈育德,孙爱明,薛志福,夏毅.中国恶性肿瘤死亡率20年变化趋势和近期预测分析[J].中华肿瘤杂志,1997,19(1):3-9. 被引量:869
  • 5Goldstein JA, Faletto MB, Romkes-Sparks M, et al. Evidence that CYP2C19 is the major (S)-mephenytoin 4'- hydroxylase in humans. Biochemistry, 1994, 33 (7): 1743-1752.
  • 6Furuta T, Shirai N, Sugimoto M, et al. Influence of CYP2C19 pharmacogenetic polymorphism on proton pump inhibitor-based therapies. Drug Metab Pharmacokinet, 2005, 20 (3): 153-167.
  • 7Chen S, Chou WH, Blouin RA, et al. The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: screening costs and influence on clinical outcomes in psychiatry. Clin Pharmacol Ther, 1996, 60 (5): 522-534.
  • 8de Morais SM, Wilkinson GR, Blaisdell J, et al. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem, 1994, 269 (22): 15419-15422.
  • 9De Morais SM, Wilkinson GR, Blaisdell J, et al. Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol, 1994, 46 (4): 594-598.
  • 10Wrighton SA, Stevens JC, Becker GW, et al. Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'- hydroxylation. Arch Biochem Biophys, 1993, 306 (1): 240-245.

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