沙美特罗/丙酸氟替卡松干粉剂和丙酸氟替卡松气雾剂治疗支气管哮喘的疗效比较

Efficacy of salmeterol/fluticasone propionate accuhaler versus fluticasone turbuhaler in the treatment of asthma

目的:比较吸入沙美特罗/丙酸氟替卡松(SM/FP)干粉剂和单用丙酸氟替卡松(FP)气雾剂治疗轻中度哮喘患者的临床疗效。方法:将60例哮喘患者随机分为两组,A组吸入SM/FP,每次50μg/100μg,bid,B组吸入FP,每次125μg,bid。测定两组患者治疗前、治疗后1个月和4个月后晨间呼气峰流速(mPEF),第1秒用力呼气容积占预计值百分比(FEV_1%pre)、第1秒用力呼气容积占用力肺活量百分比(FEV_1/FVC)和哮喘症状评分。结果:两组各项指标均有好转,治疗后1个月A组mPEF,FEV_1%pre,症状评分较B组改善明显,第4个月两组之间各项指标均有差异(P＜0．05)。结论:联合吸入低剂量糖皮质激素和β_2受体激动剂较单一吸入激素效果好。

Objective： To compare the efficacy of salmeterol/fluticasone propioante （SM/FP） combination to fluticasone （FP） alone in the treatment of mild and moderate asthma. Methods： 60 patients with asthma were randomized 1：1 to reeeive SM/FP （50μg/100μg） twice daily or FP 125μg twice daily. The efficacy was evaluated based on the improvements of maximal peak expiratory flow （ mPEF）, FEV1 % pre, FEV1/FVC and the daytime and nighttime asthma symptom scores before and after bi-therapy or mono-therapy. Results：Bi-therapy showed more significant improvements of therapeutic outcomes than mono-therapy （P 〈 0. 05）. Conclusion ： Combination of corticosteroids and β2 agonist is superior to the single inhaled corticosteroids.