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反义基因治疗高血压 被引量:1

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摘要 治疗高血压新方法——基因治疗,正随着近年来基因转移技术水平的提高和人类基因组计划的提前完成应运而生。高血压的基因治疗分为正义基因治疗和反义基因治疗,本文讨论反义基因治疗高血压的理论基础、治疗策略、面临的问题及前景展望。
出处 《国际心血管病杂志》 2006年第2期83-86,共4页 International Journal of Cardiovascular Disease
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参考文献15

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同被引文献19

  • 1赵春霞,汪培华,李宏伟,肖啸,Lee Chao,汪道文.人组织型激肽释放酶基因降低果糖诱导高血压大鼠的血压并改善高胰岛素血症[J].中国分子心脏病学杂志,2002,2(4):3-8. 被引量:3
  • 2M.Sean McMurtry,Stephen L.Archer,Dario C.Altieri,Sebastien Bonnet,Alois Haromy,Gwyneth Harry,Sandra Bonnet,Lakshmi Puttagunta,and Evangelos D.Michelakis.Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension[J].Clin Invest,2005(June),115(6):1479-1491.
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  • 5JA Martinez and D T O'connor.Somatic cell gene therapy for a trait as complex as hypertension[J].Clin Invest,1995(April),95(4):1426.
  • 6Neil A Holtzman and David Shapiro.The new genetics:Genetic testing and public policy[J].1998(March),14,316(7134):852-856.
  • 7Brian S.Zuckerbraun,Beek Yoke Chin,Barbara Wegiel,Timothy R.Billiar,Eva Czsimadia,Jayashree Rao,Larissa Shimoda,Emeka Ifedigbo,Shin Kanno,and Leo E.Carbon monoxide reverses established pulmonary hypertension[J].Exp Med,2006,September 4;203(9):2109-2119.
  • 8Hilal Al Sabti.Therapeutic angiogenesis in cardiovascular disease[J].Cardiothorac Surg,2007,249.Publisched online,2007 November 16.
  • 9Phillips MI,Mohuczy-Dominiak D,Coffey M,et al.Prolonged reduction of high blood pressure with an invivo,nonpathogenic adeno-associated viral vector delivery of AT1RmRNA antisense[J].Hypertension,1997,29(1 Pt2):374-380.
  • 10Raizade MK,Katovich MJ,Wang H,et al.Is antisense gene therapy a step in the right direction in the control of hypertension[J].Am J Physiol,1999,277(2):423-432.

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