血管老化中大电导钙激活钾通道的改变及意义
摘要
血管老化是心血管事件发生的主要危险因素之一。近年来随着“膜学说”的发展,大电导钙激活钾通道在血管老化中的改变日益受到关注,其与心血管事件的发生关系密切。本文就钙激活钾通道在血管老化中的改变和意义作一综述。
出处
《国际心血管病杂志》
2006年第2期122-125,共4页
International Journal of Cardiovascular Disease
基金
四川省自然科学基金资助项目(04jy029-019-277)
参考文献16
-
1[1]Nielsen-Kudsk JE,Boesgaard S,Aldershvile J.K+ channel opening:a new drug principle in cardiovascular medicine[J].Heart,1996,76(2):109-116.
-
2[2]Marijic J,Li Q,Song M,et al.Decreased expression of coltage and Ca2+-activated K+ channels in coronary smooth muscle during aging[J].Circ Res,2001,88(2):210-216.
-
3[3]Toro L,Marijic J,Nishimaru K,et al.Aging,ion channel expression,and vascular function[J].Vascul Pharmacol,2002,38(1):73-80.
-
4[4]Wang YW,Ding JP,Xia XM,et al.Consequences of the stoichiometry of slol α and auxiliary β subunits on functional properties of large conductance Ca2+ -activated K+ channels[J].J Neurosci,2002,22(5):1550-1561.
-
5[5]Meera P,Wallner M,Song M,et al.Large conductance voltage and calcium-dependent K+ channel,a distinct member of voltage-dependent ion channels with seven N terminal transmembrane segments (S0-S6),an extracellular N terminus,and an intracellular (S9-S10) C terminus[J].Proc Nati Acad Sci U S A,1997,94(25):14066-14071.
-
6[6]Kotlikoff M,Hall I.Hypertension:beta testing[J].J Clin Invest,2003,112(5):654-656.
-
7[7]Vogalis F,Vincent T,Qureshi I,et al.Cloning and expres sion of the large-conductance Ca2+-activated K+ channel from colonic smooth muscle[J].Am J Physiol,1996,271 (4 Pt 1):G629-G639.
-
8[8]Brenner R,Perez GJ,Bonev AD,et al.Vasoregulation by the beta1 subunit of the calcium-activated potassium channel[J].Nature,2000,407(6806):870-876.
-
9[9]McCobb DP,Fowler NL,Featherstone TA,et al.Ahuman calcium-activated potassium channel gene expressed in vascu lar smooth muscle[J].Am J Physiol,1995,269(3 Pt 2):H767-H777.
-
10[10]Santarelli LC,Chen JG,Heinemann SH,et al.The beta1 subunit enhances oxidative regulation of large-conductance calcium-activated K+ channels[J].General Physiol,2004,124(4):357-370.
-
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-
2陈睿,雷燕.非酶糖基化与血管老化的关系[J].中国动脉硬化杂志,2014,22(2):190-195. 被引量：2
-
3晓平.人造血管[J].中国科教创新导刊,1994,0(6):39-39.
-
4李萍.血管老化相关内皮细胞衰老的机制研究[J].今日健康,2014,13(2):15-15.
-
5大山俊郎,迟宝荣.血管的老化[J].国外医学（老年医学分册）,1992,13(3):102-105. 被引量：2
-
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-
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-
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-
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-
10酸梅当零食 可以抗衰老[J].浙江中西医结合杂志,2004,14(8):482-482.
