血清同型半胱氨酸水平与冠状动脉病变程度的关系

The correlation between serum homocysteine level and coronary lesion severity

目的：探讨冠心病(CHD)患者血清同型半胱氨酸(Hcy)水平与冠状动脉病变程度的相关关系。方法；对107例CHD患者及48例对照组行选择性冠状动脉造影(CAG),并记录Gensini冠脉病变积分。CAG术前取空腹血,测血清Hcy水平。结果：CHD患者血清Hcy水平明显高于对照组,血清Hcy水平与冠状动脉病变积分呈正相关(r=0．74,P=0．0001),多元逐步回归分析剔除相关因素后以上相关性仍存在。结论：高同型半胱氨酸血症是冠心病发病高危因素之一,血清Hcy水平越高,其冠脉病变程度越严重。

Objective： To investigate the correlation between serum homocysteine level and corunary lesion severity, and left ventricular systolic function in patients with coronary artery disease （CAD）. Methods：The study population consisted of 107 patients with CAD and 48 normal controls. The lesion severity of coronary arteries was assessed by Gensini coronary scoring system, and the parameters of left ventricular systolic function were evaluated by ecbocardiograpby. The fasting total serum homocysteine concentration was measured before angiograpby. Results： Serum homocysteine level in CAD group was significantly higher than in control group. A significant positive correlation was found between coronary lesion severity score and serum bomocysteine level （r= 0.74, P 〈 0. 001）. Even after adjustment for conventional risk factors such as age, sex, smoking, by multivariate stepwise regression analysis, this relationship also existed. Conclusions： The results indi cate that byperbomocysteinemia may be an independent risk factor for cardiovascular disease. Patients with high serum homocysteine level may have more severe coronary lesion and reduced left ventricular ejection fraction.