羟苯磺酸钙治疗肾病蛋白尿疗效观察

Clinical effect of calcium dobesilate on treating proteinuria of nephropathy

目的观察羟苯磺酸钙治疗肾病蛋白尿的临床疗效。方法将148例患者随机分为两组,观察组74例在常规综合治疗的基础上服用羟苯磺酸钙0.5 g,每日3次,对照组74例单用常规治疗。结果观察组4周时24小时蛋白尿较治疗前明显下降(2.49±1.02 vs 1.64±0.85)g(P<0.001);对照组4周时24小时蛋白尿较治疗前也有所减少(2.47±1.02 vs 2.20±1.01)g(P<0.01),但12周时高于治疗前水平(2.47±1.02 vs 2.60±0.98)g。两组间比较,4,8,12周差异均有统计学意义(P<0.001)。羟苯磺酸钙治疗蛋白尿的作用对肾功能正常和慢性肾衰竭者都有效,4周后24小时蛋白尿均较治疗前明显减少(2.42±0.91 vs 1.53±0.77;2.50±1.09 vs 1.75±0.93)g,差异均有统计学意义(P<0.001)。此外,该药物还可降低慢性肾衰竭血尿素氮(BUN)、肌酐(Scr)水平。结论羟苯磺酸钙具有减少肾病蛋白尿的作用,该作用对肾功能正常和慢性肾衰竭者都有效,并可降低慢性肾衰竭BUN、Scr水平。

Objective To observe the therapeutic effect of calcium dobesilate on treating proteinuria of nephropathy. Methods One hundred and forty-eight patients were randomly divided into two groups. Seventy-four cases in the observed group received calcium dobesilate（0.5 g, three times a day） plus routine methods, but the other seventy-four cases in the control group only received routine methods. Results At the point of treating four weeks, proteinuria elimination was seen in the observed group,which was markedly lower than that before treatment （2.49±1.02 vs 1.64±0.85） g/24 h（ P 〈0. 001） ,and also decreased in the control group （2.47±1.02 vs 2.20±1.01） g/24 h （ P 〈0.01）. However,the level of proteinuria was higher than that before treatment in the control group after treating twelve weeks （2.47±1.02 vs 2.60 ± 0. 98） g/d. There was significant difference on proteinuria elimination after treatment for 4, 8, 12 weeks between two groups（ P 〈0. 001）. Roles of calcium dobesilate on treating proteinuria were effective for patients with normal renal function and chronic renal failure. After treating four weeks, proteinuria in both groups was obviously lower than that before treatment （2.42±0.91 vs 1.53±0.77;2.50±1.09 vs 1.75± 0.93） g/24 h, and the difference was of statistic significance（ P 〈0. 001）. Besides, the drug still could reduce the level of blood uria nitrogen（BUN）, serum creatinine（Scr） of renal failure patients. Conclusion Calcium dobesilate could reduce proteinuria of nephropathy, which was effective for patients with normal renal function and chronic renal failure, and could reduce the level of Bun, Scr of renal failure patients.