丹参对大鼠烫伤早期肝组织含水量的影响

Effect of salvia miltiorrhizae on water content in rats during early postburn stage

目的观察大鼠严重烫伤早期肝组织含水量的变化及丹参对它们的影响。方法建立30%III度烫伤模型,88只Wistar大鼠随机分为正常对照组(A组,8只)、平衡液复苏组(B组,40只)和丹参治疗组(C组,40只)。B、C两组烫伤后立即按Parkland公式腹腔注射平衡液120ml/kg,C组在同样治疗的基础上腹腔注射丹参注射液3ml/kg,B、C两组分别于伤后3,6,12,24,48h测定肝组织含水量。结果与对照组相比较,复苏组肝组织含水量在伤后6h即明显高于对照组,48h达高峰;丹参治疗组在各相应时相点与对应的复苏组比较,两者的变化趋势基本一致,但肝组织含水量均低于复苏组,伤后6h起显著低于复苏组。结论(1)大鼠严重烫伤早期肝组织含水量即明显升高。(2)丹参可使严重烫伤早期肝损伤的肝组织含水量降低,对烫伤早期肝损伤有保护作用。

Objective To investigate the dynamical change of water content in liver during early stage postburn , and to study the effect of salvia miltiorrhizae（SM） on them. Methods Eighty--eight Wistar rats were randomly divided into three groups ： normal control group （group A） , burn group （group B） , and burn plus SM group （group C） . Rats of group B and C received a 300/00 Ⅲ-degree burn and were resuscitated immediately with lactated Ringer＇s solution （120 ml/kg/）. Additionally , rats of group C received SM at a dose of 3 ml/kg . Water content in liver was measured at 3 , 6 , 12 , 24 , 48 h after burn. Results （1） In group B , water content in liver increased remarkably at 6 hours after burn and reached the top at 48 hours postburn , the change tendency of water content in liver in group C was similar to that in group B. In comparison with group B , in group C was much lower. Conclusion （1） . water content in liver increased remarkably in rats during early postburn stage. （2） SM can reduce water content in liver and has a protective effect on liver injury of scalded rats during early stage.